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Results for "

5'-dCMPS

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Natural
Products

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17026E
    Gemcitabine triphosphate trisodium

    dFdCTP trisodium

    		 Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .
    Gemcitabine triphosphate trisodium
  • HY-17026A
    Gemcitabine triphosphate

    dFdCTP

    		 Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .
    Gemcitabine triphosphate
  • HY-W009216
    2'-Deoxycytidine-5'-monophosphate
    1 Publications Verification

    5'-dCMP; Deoxy-CMP; 2'-Deoxycytidine-5'-monophosphoric acid

    		 DNA/RNA Synthesis Infection
    2'-Deoxycytidine-5'-monophosphate (5'-dCMP) is a compound that binds to the adenovirus terminal protein with a molecular weight of 80000 daltons. 2'-Deoxycytidine-5'-monophosphate forms a covalent complex with this protein and is associated with adenovirus DNA replication .
    2'-Deoxycytidine-5'-monophosphate
  • HY-W011152
    2'-Deoxycytidine-5'-monophosphoric acid disodium
    1 Publications Verification

    dCMP disodium

    		 Endogenous Metabolite Others
    2'-Deoxycytidine-5'-monophosphoric acid disodium (dCMP disodium) is an endogenous metabolite .
    2'-Deoxycytidine-5'-monophosphoric acid disodium
  • HY-131813
    5'-dCMPS

    2'-Deoxycytidine-5'-O-monophosphorothioate

    		 Drug Derivative Others
    5'-dCMPS is an analogue of 5'-dCMP and a potential substrate, competitive inhibitor or regulator of enzymes that interact with 5'-dCMP .
    5'-dCMPS
  • HY-E70108
    Cytidylate kinase

    		PKC Others
    Cytidylate kinase catalyzes the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates .
    Cytidylate kinase

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