50 mM phosphate buffer

By Targets:	Biochemical Assay Reagents (5) CXCR (1) Factor Xa (2) Fluorescent Dye (2) Free Fatty Acid Receptor (1) Isotope-Labeled Compounds (1) Prostaglandin Receptor (1) Renin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (1)

Targets Recommended: Sodium Phosphate Cotransporter Glucose-6-Phosphate Isomerase (GPI) Carbamoyl Phosphate Synthetase (CPS) PIKfyve PI4P5K Pyruvate Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1977

100 mM Pro-Ac, 20 mM Arg, pH 5.0 buffer	Biochemical Assay Reagents	Others
100 mM Pro-Ac, 20 mM Arg, pH 5.0 buffer is a buffer solution and can be used as a reconstitution buffer for ADC products.

HY-137431

Asundexian 5 Publications Verification BAY-2433334	Factor Xa	Cardiovascular Disease
Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an *IC₅₀* of 1 nM .

HY-D1314

FAM azide, 6-isomer 6-FAM azide	Fluorescent Dye	Others
FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

HY-B1610J

Sodium Citrate Buffer, 0.5M, pH 5.0 1 Publications Verification	Biochemical Assay Reagents	Cancer
Sodium Citrate Buffer, 0.5M, pH 5.0 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 5.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .

HY-14973

Vidupiprant AMG 853	Prostaglandin Receptor	Inflammation/Immunology
Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with *IC₅₀s of 3 nM and 4 nM in buffer*, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment .

HY-167851

CCX662	CXCR	Neurological Disease Cancer
CCX662 is a selective CXCR7 inhibitor with human *IC₅₀* values of 9 nM (buffer) and 18 nM (100% human serum), and rat *IC₅₀* of 14 nM (100% rat serum). CCX662 blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4 ⁺/CXCR7 ⁺ cells. CCX662 can be used for the research of glioblastoma multiforme .

HY-D0876

POPSO	Biochemical Assay Reagents	Others
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an *IC₅₀* value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .

HY-Y1977A

100 mM Pro-Ac, pH 5.0 buffer	Biochemical Assay Reagents	Others
100 mM Pro-Ac, pH 5.0 buffer is a buffer solution and can be used as a reconstitution buffer for ADC products.

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents	Others
Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

HY-137798

Chromozym PL	Fluorescent Dye	Others
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated .

HY-177326

Ciprokiren Ro 44-9375	Renin	Cardiovascular Disease
Ciprokiren (Ro 44-9375) is a Renin inhibitor with *IC₅₀s of 0.07 and 0.65 nM for hRenin in buffer* and plasma, respectively. Ciprokiren be applied transdermally with similar hemodynamic effects without decrease of plasma renin activity or plasma immunoreactive angiotensin II. Ciprokiren has antihypertensive efficacy and can be used for hypertension research .

HY-111141

AM-3189	Free Fatty Acid Receptor	Metabolic Disease
AM-3189 is an orally active and selective GPR40 agonist with *EC₅₀* values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes .

HY-137431S

Asundexian-d3 BAY-2433334-d₃	Isotope-Labeled Compounds Factor Xa	Cardiovascular Disease
Asundexian-d₃ (BAY-2433334-d₃) is the deuterium labeled Asundexian (HY-137431). Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC₅₀ of 1 nM .

Cat. No.	Product Name	Type

HY-D1314

FAM azide, 6-isomer 6-FAM azide	Fluorescent Dyes
FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

Cat. No.	Product Name	Type

HY-Y1977

100 mM Pro-Ac, 20 mM Arg, pH 5.0 buffer	Biochemical Assay Reagents
100 mM Pro-Ac, 20 mM Arg, pH 5.0 buffer is a buffer solution and can be used as a reconstitution buffer for ADC products.

HY-B1610J

Sodium Citrate Buffer, 0.5M, pH 5.0 1 Publications Verification	Biochemical Assay Reagents
Sodium Citrate Buffer, 0.5M, pH 5.0 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 5.0 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .

HY-D0876

POPSO	Biochemical Assay Reagents
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an *IC₅₀* value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents
Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

Sodium Citrate Buffer, 0.5M, pH 5.5

Biochemical Assay Reagents

Sodium Citrate Buffer, 0.5M, pH 5.5 is a metal chelator and buffering agent. Sodium Citrate Buffer, 0.5M, pH 5.5 requires oxygen to participate in the oxidation process to reduce pink defects in cooked ground turkey, and it does not function via heme iron chelation or iron complex interaction. When mixed with 50% (by vol.) 1,3-dimethylimidazolium methyl sulfate, Sodium Citrate Buffer, 0.5M, pH 5.5 can serve as an aqueous buffering medium to maintain the catalytic efficiency of the hyperthermophilic β-glycosidase CelB for lactose hydrolysis at 80°C, while also acting as a reaction medium for CelB-catalyzed lactose hydrolysis and galactosyltransferase assays .

Cat. No.	Product Name	Target	Research Area

HY-P2435

Bz-Nle-Lys-Arg-Arg-AMC	Peptides	Others
Bz-Nle-Lys-Arg-Arg-AMC can be used for protease activity assay. In 0.1mL Tris-HCl buffer (50 mM, pH 7.8), Bz-Nle-Lys-Arg-Arg-AMC was hydrolyzed, and the release rate of AMC was observed .

HY-137798

Chromozym PL	Fluorescent Dye	Others
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated .

Cat. No.	Product Name

HY-K0801

50 bp DNA Marker
The 50 bp DNA Marker is provided in a solution of 1× DNA Loading Buffer, which can be directly used for nucleic acid electrophoresis analysis. The 250 μL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Chemical Structure

HY-137431S

Asundexian-d3
Asundexian-d₃ (BAY-2433334-d₃) is the deuterium labeled Asundexian (HY-137431). Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC₅₀ of 1 nM .

Cat. No.	Product Name		Classification

HY-D1314

FAM azide, 6-isomer 6-FAM azide		Labeling and Fluorescence Imaging Azide
FAM azide, 6-isomer (6-FAM azide) is a 6-carboxyfluorescein derivative with an azide functional group and coupling partner in copper-catalyzed azide-alkyne cycloaddition. FAM azide, 6-isomer participates in synthesis of fluorescently tagged disparlure enantiomers for pheromone-binding protein binding assays. FAM azide, 6-isomer is widely used for labeling oligonucleotides (Ex/Em = 493/517 nm) .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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