1226686-54-9
1226686-54-9
Chemical Structure
CCX662
- CAS No.: 1226686-54-9
- Formula:C28H37N5O4S
- Molecular Weight:539.69
InChIKey: OROWGUJESLHVQL-UHFFFAOYSA-N
SMILES: O=C(CCCOC1=C(N2CCN(CCC2)CC3=CSC(N4CCC(CC4)O)=N3)C5=NC=CC=C5C=C1C)O
Biological Activity: CCX662 is a selective CXCR7 inhibitor with human IC50 values of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum). CCX662 blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ cells. CCX662 can be used for the research of glioblastoma multiforme[1][2].
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CCX662 | CCX662 is a selective CXCR7 inhibitor with human IC50 values of 9 nM (buffer) and 18 nM (100% human serum), and rat IC50 of 14 nM (100% rat serum). CCX662 blocks CXCL12 binding to CXCR7, inhibits CXCR4-directed trans-endothelial migration of CXCR4+/CXCR7+ cells. CCX662 can be used for the research of glioblastoma multiforme. | |||||||||||||||||||||
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References
- [1]. Walters MJ, et al. Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer. 2014;110(5):1179-1188. [Content Brief]
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[2]. Ebsworth K, et al. The effect of the CXCR7 inhibitor CCX662 on survival in the ENU rat
model of glioblastoma. J Clin Oncol 30. 2012:e13580.
Keywords
