Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
AC1
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "AC1" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
3
3 Cited Publications
Research Areas:
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM) [1] . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta . SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation .
1
1 Cited Publications
Target:
Research Areas:
CK1-IN-3 (compound 51) is a AC1 inhibitor with an IC50s 2.22 µM for CK-1δ [1] .
Synonyms: HTS 09836; NB001
Target:
Research Areas:
NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity [1].
Synonyms: R 50547 hydrochloride
Research Areas:
Levocabastine (R 50547) hydrochloride is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine hydrochloride can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) .
Target:
Research Areas:
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain [1].
Cat. No.: HY-N10772
CAS No.: 73343-42-7
Cat. No.: HY-161024
CAS No.: 46697-00-1
Synonyms: AQB
Target:
Research Areas:
AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR-EZH2 interaction and enhances the efficacy of Tazemetostat in endometrial cancer [1].
Cat. No.: HY-P10522
CAS No.: 106128-97-6
Cat. No.: HY-P10525
CAS No.: 167278-49-1
Target:
Research Areas:
Cat. No.: HY-14277
CAS No.: 79516-68-0
Synonyms: R 50547
Research Areas:
Levocabastine (R 50547) is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) .
Cat. No.: HY-101863
CAS No.: 379218-90-3
Target:
Research Areas:
CB-6673567 is a selective AC1 inhibitor with an IC50 of 77 μM .CB-6673567blocks the choline-induced cAMP increase and can be used for cardiovascular diseases research [1].
Cat. No.: HY-171279
CAS No.: 1177418-39-1
Target:
Research Areas:
Casein kinase 1δ-IN-29 (Compound 18) is the inhibitor for p38α and casein kinase 1 that inhibits p38α, CK1δ and CK1ε with IC50 of 0.041 µM, 0.005 µM and 0.447 µM, respectively. Casein kinase 1δ-IN-29 arrests cell cycle at subG1 phase, induces apoptosis in cell AC1-M88 [1].
Cat. No.: HY-134373A
Target:
Research Areas:
Bis-Cl-ANT-ATP (tetrasodium) is a fluorescent ATP derivative, which undergo spontaneous isomerization. Bis-Cl-ANT-ATP (tetrasodium) selectively inhibits B. pertussis Adenylyl Cyclase (AC) toxin CyaA over mammalian AC1, AC2, and AC5 (Kis = 16, 1,700, 2,400, and 1,600 nM, respectively). Bis-Br-ANT-ATP (tetrasodium) can be used in the study of whooping cough [1].
Cat. No.: HY-103430
CAS No.: 108179-91-5
Research Areas:
SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM) [1] . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta . SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation .
Cat. No.: HY-RS05088
Target:
Research Areas:
FRA10AC1 Human Pre-designed siRNA Set A contains three designed siRNAs for FRA10AC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00326
Target:
Research Areas:
ADCY1 Human Pre-designed siRNA Set A contains three designed siRNAs for ADCY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-101279R
CAS No.: 133406-29-8
Target:
Research Areas:
ST034307 (Standard) is the analytical standard of ST034307 (HY-101279). This product is intended for research and analytical applications. ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
Cat. No.: HY-RS10637
Target:
Research Areas:
PLAAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for PLAAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174151
CAS No.: 203923-65-3
Target:
Research Areas:
XSJ110 is a potent irreversible topoisomerase I (Topo I) inhibitor with an IC50 value of 0.133 μM. XSJ110 blocks DNA topoisomerization, induces DNA double-strand breaks, and triggers cell cycle arrest at G0/G1 phase, inducing tumor cell apoptosis. XSJ110 is promising for research of ampullary carcinoma (AC) .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
