Casein kinase 1δ-IN-29 

Casein kinase 1δ-IN-29 (Compound 18) is the inhibitor for p38α and casein kinase 1 that inhibits p38α, CK1δ and CK1ε with IC₅₀ of 0.041 µM, 0.005 µM and 0.447 µM, respectively. Casein kinase 1δ-IN-29 arrests cell cycle at subG1 phase, induces apoptosis in cell AC1-M88^[1].

506.55

C₂₆H₂₃FN₄O₄S

1177418-39-1

CS(C1=NC(C2=CC=C(C=C2)F)=C(C3=CC=NC(NC(/C=C/C4=C(C=C(C=C4)OC)OC)=O)=C3)N1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Peifer C, et al., 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem. 2009 Dec 10;52(23):7618-30.  [Content Brief]