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Results for "

AD 4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (6) Bacterial (1) Cholinesterase (ChE) (1) Complement System (1) DNA/RNA Synthesis (2) Drug Metabolite (1) Endogenous Metabolite (2) Ferroptosis (1) Fungal (1) Histone Demethylase (3) iGluR (1) Isotope-Labeled Compounds (12) Phosphatase (1) PPAR (2) PROTACs (1) Reactive Oxygen Species (ROS) (2)
By Research Areas:	Cancer (8) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148807

Zavondemstat QC8222 free base; TACH 101 free base	Histone Demethylase Apoptosis	Cancer
Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-B0579S

Cyclosporin A-d4 1 Publications Verification Cyclosporine A-d₄; Ciclosporin A-d₄; CsA-d₄	Isotope-Labeled Compounds Antibiotic Complement System Phosphatase	Inflammation/Immunology Cancer
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-149428

*AD4* 1 Publications Verification	PROTACs	Cancer
AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC₅₀: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .

HY-146926S

16:0 Coenzyme A-d4	Isotope-Labeled Compounds	Others
16:0 Coenzyme A-d₄ is deuterium labeled 16:0 Coenzyme A.

HY-18260S4

Bisphenol A-d4	Endogenous Metabolite	Metabolic Disease
Bisphenol A-d₄ is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-108385

Ochratoxin A-D4	Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis PPAR Reactive Oxygen Species (ROS) Apoptosis Fungal	Inflammation/Immunology Cancer
Ochratoxin A-D4 (Phe-OTA-D4) is the deuterium labeled Ochratoxin A. Ochratoxin A is an orally active food-borne mycotoxin that can cross the blood-brain barrier. Ochratoxin A is a secondary metabolite of fungi belonging to the genera Aspergillus and Penicillium, and is classified as a Group 2B carcinogen. Ochratoxin A exerts its effects through multiple pathways, including inducing oxidative stress, inhibiting mitochondrial respiration, causing oxidative DNA damage, disrupting the PPAR-γ-CD36 axis, inducing immunosuppression, generating ROS, mediating mitochondria-dependent apoptosis, inhibiting glutamate uptake, triggering demyelination and neuroinflammation, inducing DNA hypomethylation, and inhibiting cell proliferation. Ochratoxin A can induce nephrotoxicity, hepatotoxicity, immunotoxicity, and neurotoxicity, and also exhibits mutagenicity, teratogenicity, and carcinogenicity.

HY-113209S

8-Isoprostaglandin F2α-d4 8-iso-PGF2α-d₄	Isotope-Labeled Compounds	Metabolic Disease
8-Iso-PGF2a-d₄ (8-iso Prostaglandin F2α-d₄) is an active compound. 8-Iso-PGF2a-d₄ can be used the internal standard .

HY-146927S

24:0 Coenzyme A-d4	Isotope-Labeled Compounds	Others
24:0 Coenzyme A-d₄ is deuterium labeled 24:0 Coenzyme A.

HY-143997S

*(Rac)-Nicotine EP impurity A-d4* hydrochloride**	Drug Metabolite Isotope-Labeled Compounds	Others
(Rac)-Nicotine EP impurity A-d₄ (hydrochloride) is the deuterium labeled (Rac)-Nicotine EP impurity A hydrochloride .

HY-148807A

Zavondemstat L-lysine QC8222; TACH 101	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) L-lysine is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat L-lysine induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat L-lysine suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat L-lysine can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-114977S

Avenanthramide A-d4	Isotope-Labeled Compounds Apoptosis DNA/RNA Synthesis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

HY-17387S1

*(-)-Huperzine A-d4* hydrochloride** Huperzine A-d₄	iGluR Cholinesterase (ChE) Apoptosis Isotope-Labeled Compounds	Neurological Disease
(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-143969S

KL140061A-d4	Isotope-Labeled Compounds	Others
KL140061A-d₄ is the deuterium labeled KL140061A .

HY-W738533

Pioglitazone-d4 hydrochloride U 72107A-d₄; AD 4833-d₄	Isotope-Labeled Compounds PPAR Ferroptosis	Cancer
Pioglitazone-d₄ hydrochloride (U 72107A-d₄; AD 4833-d₄) is the deuterium labeled Pioglitazone hydrochloride (HY-14601). Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC₅₀s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.

HY-B0395S

Sitafloxacin-d4 DU6859a-d₄	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Sitafloxacin-d₄ (DU6859a-d₄) is deuterium labeled Sitafloxacin. Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

HY-148807C

Zavondemstat sodium QC8222 sodium; TACH 101 sodium	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) sodium is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat sodium induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat sodium suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat sodium can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-179245S

(±)EP-0226A-d4	Isotope-Labeled Compounds	Others
(±)EP-0226A-d₄ is the deuterium labeled (±)EP-0226A.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703128

	NR5A1 Protein, Human (His, Strep) AD4BP; FTZF1; SF1	Human	E. coli
	NR5A1 Protein, Human (His, Strep) is the recombinant human-derived NR5A1, expressed by E. coli , with Strep, His labeled tag. ,

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HY-B0579S

Cyclosporin A-d4 1 Publications Verification
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-146926S

16:0 Coenzyme A-d4
16:0 Coenzyme A-d₄ is deuterium labeled 16:0 Coenzyme A.

HY-18260S4

Bisphenol A-d4
Bisphenol A-d₄ is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

Bisphenol A-d4

Bisphenol A-d₄ is the deuterium labeled Bisphenol A . Bisphenol A is a phenolic, organic synthetic compound widely used in the production of polycarbonate plastics and epoxy resins. Bisphenol A is a reproductive, developmental, and systemic toxicant, often classified as an endocrine-disrupting compound (EDC). Bisphenol A is associated with many diseases, including cardiovascular diseases, respiratory diseases, diabetes, kidney diseases, obesity, and reproductivedisorders .

HY-113209S

8-Isoprostaglandin F2α-d4
8-Iso-PGF2a-d₄ (8-iso Prostaglandin F2α-d₄) is an active compound. 8-Iso-PGF2a-d₄ can be used the internal standard .

HY-146927S

24:0 Coenzyme A-d4
24:0 Coenzyme A-d₄ is deuterium labeled 24:0 Coenzyme A.

HY-143997S

*(Rac)-Nicotine EP impurity A-d4* hydrochloride**
(Rac)-Nicotine EP impurity A-d₄ (hydrochloride) is the deuterium labeled (Rac)-Nicotine EP impurity A hydrochloride .

HY-114977S

Avenanthramide A-d4
Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

Avenanthramide A-d4

Avenanthramide A-d₄ is the deuterium labeled Avenanthramide A (HY-114977). Avenanthramide A is an orally active phytoalexin that targets the RNA helicase DDX3 with a K_D of 8.8 μM. Avenanthramide A induces mitochondrial swelling and increased ROS production, and triggers apoptosis in CRC cells. Avenanthramide A inhibits smooth muscle cell proliferation and enhances nitric oxide production. Avenanthramide A can be used in research on colorectal cancer and atherosclerosis .

HY-17387S1

*(-)-Huperzine A-d4* hydrochloride**
(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-143969S

KL140061A-d4
KL140061A-d₄ is the deuterium labeled KL140061A .

HY-W738533

Pioglitazone-d4 hydrochloride
Pioglitazone-d₄ hydrochloride (U 72107A-d₄; AD 4833-d₄) is the deuterium labeled Pioglitazone hydrochloride (HY-14601). Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC₅₀s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.

HY-B0395S

Sitafloxacin-d4
Sitafloxacin-d₄ (DU6859a-d₄) is deuterium labeled Sitafloxacin. Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

Sitafloxacin-d4

Sitafloxacin-d₄ (DU6859a-d₄) is deuterium labeled Sitafloxacin. Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection .

HY-179245S

(±)EP-0226A-d4
(±)EP-0226A-d₄ is the deuterium labeled (±)EP-0226A.

Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (1) WB (1)
Isotype:	IgG (1) IgG2 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810352

	Steroidogenic Factor 1 Antibody (YA9674) AD4BP, ELP, FTZ1, FTZF1, hSF-1, POF7, SF-1, SF1, SPGF8, SRXY3	IHC-P	Human, Mouse, Rat
	Steroidogenic Factor 1 Antibody (YA9674) is a Mouse-derived and non-conjugated IgG2 Monoclonal antibody, targeting to Steroidogenic Factor 1.

HY-P83421

	Steroidogenic Factor 1 Antibody (YA3166) AD4BP; ELP; FTZ1; FTZF1; hSF 1; NR5A1; POF7; SF1; SPGF8; SRXY3; STF1; SF-1	WB	Human, Mouse, Rat
	Steroidogenic Factor 1 Antibody (YA3166) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Steroidogenic Factor 1.

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