Steroidogenic Factor 1 Antibody (YA9674)
(Synonyms: AD4BP, ELP, FTZ1, FTZF1, hSF-1, POF7, SF-1, SF1, SPGF8, SRXY3)Steroidogenic Factor 1 Antibody (YA9674) is a Mouse-derived and non-conjugated IgG2 Monoclonal antibody, targeting to Steroidogenic Factor 1.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150 |
Product Details
Steroidogenic Factor 1 Antibody (YA9674) is a Mouse-derived and non-conjugated IgG2 Monoclonal antibody, targeting to Steroidogenic Factor 1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 51.5 kDa;
Entrez Gene: 2516
Recombinant protein fragment of human NR5A1(aa1-260) produced in E.coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Steroidogenic Factor 1 is a Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: High expressed in the adrenal cortex, the ovary, the testis, and the spleen. -
Isoforms & Post-Translational Modification
Steroidogenic Factor 1 has an amino acid length of 461, molecular weight is 51636 Da.
Acetylation stimulates the transcriptional activity -
Subunit
Binds DNA as a monomer.
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SwissProt ID
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Synonyms
AD4BP, ELP, FTZ1, FTZF1, hSF-1, POF7, SF-1, SF1, SPGF8, SRXY3
Documentation
References
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