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Results for "

Aminopiperidine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Antibiotic (1) Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (3) Cadherin (1) Caspase (1) CD38 (1) CGRP Receptor (1) Checkpoint Kinase (Chk) (1) Cyclin G-associated Kinase (GAK) (1) Drug Intermediate (2) Endothelin Receptor (1) Ephrin Receptor (1) GCGR (1) Glutaminase (1) GnRH Receptor (1) Insulin Receptor (1) Isotope-Labeled Compounds (2) Melanocortin Receptor (1) Neurokinin Receptor (1) Parasite (1) PI3K (1) PSMA (2) Radionuclide-Drug Conjugates (RDCs) (4) Renin (1) Somatostatin Receptor (5) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Endocrinology (2) Infection (1) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (5)

By Targets:

Amyloid-β (1)

Antibiotic (1)

Apoptosis (1)

Bacterial (1)

Bcl-2 Family (1)

Biochemical Assay Reagents (3)

Cadherin (1)

Caspase (1)

CD38 (1)

CGRP Receptor (1)

Checkpoint Kinase (Chk) (1)

Cyclin G-associated Kinase (GAK) (1)

Drug Intermediate (2)

Endothelin Receptor (1)

Ephrin Receptor (1)

GCGR (1)

Glutaminase (1)

GnRH Receptor (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (2)

Melanocortin Receptor (1)

Neurokinin Receptor (1)

Parasite (1)

PI3K (1)

PSMA (2)

Radionuclide-Drug Conjugates (RDCs) (4)

Renin (1)

Somatostatin Receptor (5)

VEGFR (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (1)

Endocrinology (2)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (4)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4070

Insulin icodec	Insulin Receptor	Metabolic Disease
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA_1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .

HY-P5362

NODAGA-LM3	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Neurological Disease Cancer
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-P2336A

CCZ01048 TFA 3 Publications Verification	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .

HY-145933

BJJF078	Glutaminase	Inflammation/Immunology
BJJF078 is an aminopiperidine derivative. BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme (TG2) activity, IC₅₀ values of 41 and 54 nM, respectively. BJJF078 also inhibits the close related enzyme TG1, with an IC₅₀ of 0.16 μM. BJJF078 can be used for Multiple sclerosis (MS) research .

HY-40002

4-Boc-Aminopiperidine	Biochemical Assay Reagents	Others
4-Boc-Aminopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-40028

(S)-3-Boc-aminopiperidine	Biochemical Assay Reagents	Others
(S)-3-Boc-aminopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-18006

NKP608 1 Publications Verification	Neurokinin Receptor Wnt Bcl-2 Family β-catenin Cyclin G-associated Kinase (GAK) VEGFR Caspase Cadherin Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
NKP608 is a non-peptidic derivative of 4-aminopiperidine, a highly selective, orally active, neurokinin-1 (NK₁) receptor antagonist with IC₅₀ of 2.6 nM. NKP608 is active both in vitro and in vivo, showing extremely low affinity for NK₂, NK₃ receptors. NKP608 exerts its effects by blocking the NK₁ receptor, regulate cell proliferation and apoptosis, affect neurotransmitter functions and gastric mucosal repair mechanisms, and suppress the Wnt/β-catenin pathway in antitumor research. NKP608 is applicable to research related to various diseases, including cough, anxiety disorders, depression, gastric mucosal injury, and colorectal cancer .

HY-P10341

ZP3022	GCGR	Metabolic Disease
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-49764

*(2R,5S)-1-tert-Butyl 2-ethyl 5-aminopiperidine-1,2-dicarboxylate*	Drug Intermediate	Others
(2R,5S)-1-tert-Butyl 2-ethyl 5-aminopiperidine-1,2-dicarboxylate is a drug intermediate for synthesis of various active compounds.

HY-40029

(S)-1-Boc-3-aminopiperidine (S)-(+)-3-Amino-1-boc-piperidine	Biochemical Assay Reagents Drug Intermediate Checkpoint Kinase (Chk) PI3K	Others
(S)-1-Boc-3-aminopiperidine is a key intermediate for the synthesis of various novel inhibitors, such as CHK1 inhibitors and PI3Kδ inhibitors .

HY-W088589S

*(S)-3-Aminopiperidine-2,6-dione-d1 hydrochloride*	Isotope-Labeled Compounds	Others
(S)-3-Aminopiperidine-2,6-dione-d hydrochloride is the deuterium labeled (S)-3-Aminopiperidine-2,6-dione hydrochloride .

HY-W088629S

*(R)-3-Aminopiperidine-2,6-dione-d1 hydrochloride*	Isotope-Labeled Compounds	Others
(R)-3-Aminopiperidine-2,6-dione-d hydrochloride is the deuterium labeled (R)-3-Aminopiperidine-2,6-dione hydrochloride .

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P10472

Azaline B	GnRH Receptor	Endocrinology
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC₅₀ of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P11243

EphA4 agonist compound 23	Ephrin Receptor	Neurological Disease
EphA4 agonist compound 23 is a novel EphA4 agonist peptide mimic. EphA4 agonist compound 23 exhibits high affinity, high selectivity, and significant receptor activation ability. EphA4 agonist compound 23 is commonly used in the study of neurodegenerative diseases .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-P5362A

NODAGA-LM3 TFA	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-P2075

EMD 55068	Renin	Endocrinology
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .

HY-P10876

mcK6A1	Amyloid-β	Neurological Disease
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .

HY-P11769

RM2	CGRP Receptor	Cancer
RM2 is a GRPr antagonist. RM2 selectively binds to GRPr, blocks agonist-induced receptor internalization, and inhibits agonist-triggered intracellular calcium mobilization. RM2 can be used in studies related to prostate cancer .

HY-P11488

JR11-PEG3-DOTA-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

HY-P11485

JR11-PEG3-HBED-CC-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

4-Boc-Aminopiperidine	Biochemical Assay Reagents
4-Boc-Aminopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

(S)-3-Boc-aminopiperidine	Biochemical Assay Reagents
(S)-3-Boc-aminopiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

(S)-1-Boc-3-aminopiperidine (S)-(+)-3-Amino-1-boc-piperidine	Biochemical Assay Reagents
(S)-1-Boc-3-aminopiperidine is a key intermediate for the synthesis of various novel inhibitors, such as CHK1 inhibitors and PI3Kδ inhibitors .

Cat. No.	Product Name	Target	Research Area