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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
BH3 domain
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "BH3 domain" in MCE Product Catalog:
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3 Cited Publications
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BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
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1 Cited Publications
Cat. No.: HY-161276
CAS No.: 692774-37-1
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BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers. .
Cat. No.: HY-P5328
CAS No.: 505070-09-7
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Cat. No.: HY-P5342
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Cat. No.: HY-P1562
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Cat. No.: HY-P2499A
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Cat. No.: HY-P2468
CAS No.: 331762-68-6
Synonyms: BADBH3 103-127 (human); BADBH3 (human)
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Cat. No.: HY-P0300
CAS No.: 300349-67-1
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Cat. No.: HY-P1733
Synonyms: BMF-Y
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BMf-BH3 (BMF-Y) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 can be used in cancer-related research .
Cat. No.: HY-149681
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Beclin1-Bcl-2 interaction inhibitor 1 is a Beclin1 and Bcl-2 interaction inhibitor with an IC50 value of 4.4 nM. Beclin1-Bcl-2 interaction inhibitor 1 disrupts the binding of the Bcl-2-Beclin 1 BH3 domain. Beclin1-Bcl-2 interaction inhibitor 1 can be used in the research of cancer and neurodegenerative diseases .
Cat. No.: HY-P5341
CAS No.: 505070-08-6
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Cat. No.: HY-P5330
CAS No.: 505070-10-0
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Cat. No.: HY-P5324
CAS No.: 505070-07-5
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Cat. No.: HY-161577
CAS No.: 701231-39-2
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BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells .
Cat. No.: HY-P1562A
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Cat. No.: HY-P5329
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Cat. No.: HY-P2499
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Cat. No.: HY-P1733A
Synonyms: BMF-Y TFA
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BMf-BH3 TFA (BMF-Y TFA) is a pro-apoptotic (apoptosis) protein containing only the BH3 domain, and also serves as a cellular stress sentinel for actin cytoskeleton signaling. BMf-BH3 TFA binds to pro-survival Bcl-2 family members via its BH3 domain to block their anti-apoptotic functions. BMf-BH3 TFA can be used in cancer-related research .
Cat. No.: HY-161732
CAS No.: 2982663-28-3
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GQN-B37-E is a potent selective binder and inhibitor of MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range (Ki = 0.6 μM) without apparent binding to BCL-2 or BCL-XL .
Cat. No.: HY-P7662
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BID; Human BID Coding Sequence; BH3 Interacting domain Death Agonist; Apoptic Death Agonist; BH3-Interacting domain Death Agonist; Desmocollin Type 4; P22 BID; BID Isoform Si6; BH3 Interacting domain Death Agonist Si6 Isoform; FP497
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
