1. Apoptosis
  2. Bcl-2 Family
  3. Bak BH3

Bak BH3 

Cat. No.: HY-P0300
Handling Instructions

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bak BH3 Chemical Structure

Bak BH3 Chemical Structure

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Description

Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.

IC50 & Target[1]

Bcl-xL

 

In Vitro

Bak BH3 peptide antagonize the protective effects of microinjected Bcl-xL in α-Fas-treated HeLa cells, whereas a mutant Bak BH3 peptide that no longer binds Bcl-xL is inactive[1].

Molecular Weight

1724.90

Formula

C₇₂H₁₂₅N₂₅O₂₄

Sequence

Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg

Sequence Shortening

GQVGRQLAIIGDDINR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

Cells are plated in complete DMEM in 96-well tissue culture plates at 4×103/well. After 24 h, cells are washed with PBS and treated with peptides (50 μM) in SF-DMEM. Cell viability is determined by staining unfixed cells with calcein AM/ethidium homodimer, followed by microscopic analysis of cell staining and cellular morphology on a Nikon Diaphot 300 inverted microscope equipped with a fluorescence module.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Bak BH3Bak BH 3Bak BH-3Bcl-2 FamilyInhibitorinhibitorinhibit

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Bak BH3
Cat. No.:
HY-P0300
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