2982663-28-3
2982663-28-3
Chemical Structure
GQN-B37-E
- CAS No.: 2982663-28-3
- Formula:C29H23ClN4O4
- Molecular Weight:526.97
InChIKey: VWXROMVQLONCLB-ITMPFJHPSA-N
SMILES: O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC(/C=C/C3=CN(C4=CC=CC(Cl)=C4)N=C3C5=CC=C(O)C=C5)=O
Biological Activity: GQN-B37-E is a potent selective binder and inhibitor of MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range (Ki = 0.6 μM) without apparent binding to BCL-2 or BCL-XL[1].
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GQN-B37-E | GQN-B37-E is a potent selective binder and inhibitor of MCL-1. GQN-B37-E binds to the BH3-domain-binding pocket in MCL-1. GQN-B37-E exhibits binding affinity for MCL-1 at the submicromolar range (Ki = 0.6 μM) without apparent binding to BCL-2 or BCL-XL. | |||||||||||||||||||||
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References
Keywords
