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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
BMX Kinase
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "BMX Kinase" in MCE Product Catalog:
7
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Research Areas:
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys 496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
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3 Cited Publications
Synonyms: CHMFL-BMX 078
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CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
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Flixebrutinib (TL-895) is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor. Flixebrutinib is active against recombinant BTK (average IC50: 1.5 nM) and inhibits only three additional kinases BLK, BMX (IC50 = 1.6 nM) and TXK with IC50 within tenfold of BTK activity. Flixebrutinib inhibits BTK auto-phosphorylation at the Y223 phosphorylation site (IC50: 1-10 nM). The Flixebrutinib effectively inhibits the production of inflammatory factors such as IL-8, IL-1β, MCP-1 and TNF-α by monocytes or macrophages, and reduces the chemotactic migration of MF cells towards SDF-1. Flixebrutinib is used be for studies of chronic lymphocytic leukemia (CLL), myelofibrosis (MF), and B-cell malignancies .
Cat. No.: HY-174142
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IHMT-15130 is a highly potent irreversible BMX kinase inhibitor (IC50=1.47 nM). IHMT-15130 inhibits the secretion of inflammatory cytokines, blocks inflammatory signaling pathways, and alleviates Angiotensin II-induced myocardial hypertrophy in mice. IHMT-15130 is promising for research of myocardial hypertrophy .
Cat. No.: HY-117900
CAS No.: 1609465-89-5
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PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively .
Cat. No.: HY-117900A
CAS No.: 1609465-88-4
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(Rac)-PF-0625011 is a racemate of PF-06250112. PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor and shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC .
Cat. No.: HY-148594
CAS No.: 2573048-11-8
BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997) .
Cat. No.: HY-187351
CAS No.: 3132799-96-0
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BMX-IN-4 is a covalent BMX kinase inhibitor with an IC50 of 1.78 nM and a Ki of 0.158 μM. BMX-IN-4 forms a covalent bond with BMX kinase. BMX-IN-4 is applicable to the research of hepatocellular carcinoma .
Cat. No.: HY-101267R
CAS No.: 1808288-51-8
Synonyms: CHMFL-BMX 078 (Standard)
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CHMFL-BMX-078 (Standard) is the analytical standard of CHMFL-BMX-078 (HY-101267). This product is intended for research and analytical applications. CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
Cat. No.: HY-P701711
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMX; Cytoplasmic Tyrosine-Protein Kinase BMX; BMX Non-Receptor Tyrosine Kinase; BTK-Like On X Chromosome; ETK; Etk/BMX Cytosolic Tyrosine Kinase; PSCTK3; NTK38 Tyrosine Kinase; Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein; PSCTK2; Epithelial A
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Cat. No.: HY-P701712
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMX; Cytoplasmic Tyrosine-Protein Kinase BMX; BMX Non-Receptor Tyrosine Kinase; BTK-Like On X Chromosome; ETK; Etk/BMX Cytosolic Tyrosine Kinase; PSCTK3; NTK38 Tyrosine Kinase; Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein; PSCTK2; Epithelial A
Species:
Source:
Cat. No.: HY-P706020
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: BMX; Cytoplasmic Tyrosine-Protein Kinase BMX; BMX Non-Receptor Tyrosine Kinase; BTK-Like On X Chromosome; ETK; Etk/BMX Cytosolic Tyrosine Kinase; PSCTK3; NTK38 Tyrosine Kinase; Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein; PSCTK2; Epithelial A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
