2573048-11-8
2573048-11-8
Chemical Structure
BTK-IN-23
- CAS No.: 2573048-11-8
- Formula:C27H28N6O2
- Molecular Weight:468.55
IUPAC Name: (R)-1-(3-(4-amino-3-(2,6-dimethyl-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
InChIKey: XNVVTSSPSNFSCT-LJQANCHMSA-N
SMILES: C=CC(N1CCC[C@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=C(C)C=C(C=C4C)OC5=CC=CC=C5)=O
Biological Activity: BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1].
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BTK-IN-23 | BTK-IN-23 is a BTK inhibitor (IC50: 12.8 nM). BTK-IN-23 also inhibits BLX and BMX with IC50s of 35.6 and 5.7 nM respectively. BTK-IN-23 shows improved kinase selectivity compared to Ibrutinib (HY-10997). | |||||||||||||||||||||
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References
Keywords
