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BRs

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By Targets:	Biochemical Assay Reagents (1) Bombesin Receptor (8) Calcium Channel (2) Environmental Pollutants (1) Herbicide (1) NO Synthase (2) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W074890

Palmitoylglycine 1 Publications Verification N-palmitoyl glycine	Calcium Channel NO Synthase	Neurological Disease Inflammation/Immunology
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

HY-101844

ML-18	Bombesin Receptor	Cancer
ML-18 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC₅₀ of 4.8 μM.

HY-14342

MK-5046 2 Publications Verification	Bombesin Receptor	Metabolic Disease
MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC₅₀ and an EC₅₀ value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .

HY-W014815

BPBA 2-Bromopyridine-5-boronic acid	Biochemical Assay Reagents	Others
BPBA (2-Bromopyridine-5-boronic acid) is a new labeling reagent. BPBA is used to derivatize brassinosteroids (BRs). BPBA is used for biomarker analysis of exposure to environmental pollutants such as styrene and 1,3-butadiene .

HY-P1423A

BA 1 TFA	Bombesin Receptor	Metabolic Disease Cancer
BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-136376

Mefenpyr-diethyl	Environmental Pollutants Herbicide	Others
Mefenpyr-diethyl is a pyrazoline-type herbicide safener that functions to enhance lipid biosynthesis. Mefenpyr-diethyl effectively prevents herbicide-induced phytotoxic damage caused by herbicides such as fenoxaprop-p-ethyl (HY-B2013) and mesosulfuron-methyl (HY-126987) by protecting cereal crops including wheat. Mefenpyr-diethyl significantly increases lipid content in wheat either when applied alone or in combination with the herbicide fenoxaprop-p-ethyl. The mechanism of action of Mefenpyr-diethyl does not involve the induction of glutathione S-transferase (GST) activity in wheat .

HY-W074890R

Palmitoylglycine (Standard) N-palmitoyl glycine (Standard)	Reference Standards Calcium Channel NO Synthase	Neurological Disease Inflammation/Immunology
Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

HY-14342A

(R)-MK-5046	Bombesin Receptor	Metabolic Disease
(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC₅₀ and an EC₅₀ value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity .

HY-18612

MK-7725	Bombesin Receptor	Metabolic Disease
MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC₅₀ of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC₅₀ of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity .

HY-W681071

BRS-3 receptor agonist-2	Bombesin Receptor	Neurological Disease
BRS-3 receptor agonist-2 (compound 2) is a potent BRS-3 receptor agonist, with an EC₅₀ of 2.5 nM for mouse BRS-3 receptor .

HY-P1423

BA 1	Bombesin Receptor	Metabolic Disease Cancer
BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-RS01636

Brs3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Brs3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brs3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brs3 Rat Pre-designed siRNA Set A Brs3 Rat Pre-designed siRNA Set A

HY-RS01635

Brs3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Brs3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brs3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brs3 Mouse Pre-designed siRNA Set A Brs3 Mouse Pre-designed siRNA Set A

HY-RS01634

BRS3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BRS3 Human Pre-designed siRNA Set A contains three designed siRNAs for BRS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BRS3 Human Pre-designed siRNA Set A BRS3 Human Pre-designed siRNA Set A

HY-P11768

AMBA	Bombesin Receptor	Cancer
AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand with a human IC₅₀ of 0.82 nM and a human K_i of 0.65 nM. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer .

Cat. No.	Product Name	Target	Research Area

HY-P1423A

BA 1 TFA	Bombesin Receptor	Metabolic Disease Cancer
BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-P1423

BA 1	Bombesin Receptor	Metabolic Disease Cancer
BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC₅₀s of 6, 0.4, 2.5 nM .

HY-P11768

AMBA	Bombesin Receptor	Cancer
AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand with a human IC₅₀ of 0.82 nM and a human K_i of 0.65 nM. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer .

Palmitoylglycine 1 Publications Verification N-palmitoyl glycine	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Calcium Channel NO Synthase
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

Palmitoylglycine (Standard) N-palmitoyl glycine (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Calcium Channel NO Synthase
Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

Brs3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Brs3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Brs3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Brs3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Brs3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Brs3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

BRS3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BRS3 Human Pre-designed siRNA Set A contains three designed siRNAs for BRS3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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BRs

Inhibitors & Agonists

Peptides

NaturalProducts

Oligonucleotides

Natural
Products