CCNA2

By Targets:	Akt (1) Heme Oxygenase (HO) (2) MyD88 (2) NF-κB (3) p38 MAPK (3) PERK (1) PI3K (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W097625

6-Methoxyflavone	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO)	Neurological Disease Inflammation/Immunology Cancer
6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the *CCNA2/CDK2/p21CIP*1 signaling pathway in HeLa cells. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases ^[2] .

HY-RS02117

CCNA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCNA2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCNA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCNA2 Human Pre-designed siRNA Set A CCNA2 Human Pre-designed siRNA Set A

HY-RS18168

Ccna2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccna2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccna2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccna2 Mouse Pre-designed siRNA Set A Ccna2 Mouse Pre-designed siRNA Set A

HY-RS24642

Ccna2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccna2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccna2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccna2 Rat Pre-designed siRNA Set A Ccna2 Rat Pre-designed siRNA Set A

HY-174321

A2073	p38 MAPK PI3K Akt NF-κB	Cancer
A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways. A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia.

HY-W097625R

6-Methoxyflavone (Standard)	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO) Reference Standards PERK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W097625

6-Methoxyflavone	Flavonoids Flavones Thymelaeaceae Plants Pimelea simplex F.Muell. Source Classification	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO)
6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the *CCNA2/CDK2/p21CIP*1 signaling pathway in HeLa cells. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases ^[2] .

HY-W097625R

6-Methoxyflavone (Standard)	Structural Classification Flavonoids Flavones Thymelaeaceae Plants Pimelea simplex F.Muell. Source Classification	Toll-like Receptor (TLR) MyD88 p38 MAPK NF-κB Heme Oxygenase (HO) Reference Standards PERK
6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases ^[2] .

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (2)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703551

	CCNA2 Protein, Human CCN1; CCNA; Cyclin-A2	Human	E. coli
	CCNA2 Protein, Human is the recombinant human-derived CCNA2 protein, expressed by E. coli, with tag free tag.

HY-P702675

	*CDK2-CCNA2* Protein, Human (Active, sf9, GST, His)** CDK2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2)	Human	Sf9 insect cells
	CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2-CCNA2 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK2-CCNA2, expressed by Sf9 insect cells, with N-6*His, N-GST labeled tag.

HY-P702671

	*CDK1-CCNA2* Protein, Human (Active, sf9, GST, His)** CDK1; cyclin-dependent kinase 1; CDC2, cell division cycle 2, G1 to S and G2 to M; CDC28A; p34 protein kinase; cell cycle controller CDC2; cell division protein kinase 1; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; CDC2; P34CDC2; MGC111195; DKFZp686L20222	Human	Sf9 insect cells
	The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1-CCNA2 Protein, Human (sf9, GST, His) is the recombinant human-derived CDK1-CCNA2, expressed by Sf9 insect cells, with N-His, N-GST labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83591

	Cyclin A2 Antibody (YA3336) CCN1; CCNA; CCNA1; CCNA2; CT146; Cyclin-A; Cyclin-A1; Cyclin-A2	WB, IP	Human
	Cyclin A2 Antibody (YA3336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

HY-P83591A

	Cyclin A2 Antibody (YA3336)(PBS only) CCN1; CCNA; CCNA1; CCNA2; CT146; Cyclin-A; Cyclin-A1; Cyclin-A2	WB, IP	Human
	Cyclin A2 Antibody (YA3336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

HY-P80096

	Cyclin A2 Antibody (YA487)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Cyclin A2 Antibody (YA487) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin A2.

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Cat. No.	Product Name		Classification

HY-RS02117

CCNA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCNA2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCNA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18168

Ccna2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccna2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccna2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24642

Ccna2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccna2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccna2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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