2834742-70-8
Chemical Structure
A2073
- CAS No.: 2834742-70-8
- Formula:C33H37NO7
- Molecular Weight:559.65
InChIKey: CCAZXUOCJKCMCT-HYEGGMENSA-N
SMILES: O=C(CN1CCCCC1)O[C@@H]2C[C@@H](C3=CC=CC=C3)[C@@]4(C5=CC=C(OC)C=C5)[C@]2(O)C6=C(OC)C=C(OC)C=C6O4
Biological Activity: A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways. A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia[1].
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A2073 | A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways. A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia. | |||||||||||||||||||||
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Keywords
