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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
CHD 1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "CHD 1" in MCE Product Catalog:
Cat. No.: HY-170565
CAS No.: 3041166-70-2
CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo .
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1 Cited Publications
Cat. No.: HY-159989
CAS No.: 3118919-69-7
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UNC10142 (Compound 44) is a first-in-class small molecule antagonist of CHD1 that binds with an IC50 value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells .
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CHD1Li 6.11 is a potent and orally active Chromodomain Helicase DNA Binding Protein 1 Like (CHD1L) (oncogenic gene) inhibitor (IC50 = 3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 can inhibit EMT, induce mesenchymal-epithelial transition (reverse EMT) and promote apoptosis in tumor organoid models. CHD1Li 6.11 can be used for the research of cancer, such as colorectal cancer .
Cat. No.: HY-RS02605
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CHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17405
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Chd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23860
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Chd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS02606
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CHD1L Human Pre-designed siRNA Set A contains three designed siRNAs for CHD1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24114
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Chd1l Rat Pre-designed siRNA Set A contains three designed siRNAs for Chd1l gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-185041
CAS No.: 1251542-88-7
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CHD1L-IN-2 is a CHD1L inhibitor and exhibits cytotoxicity against tumor cells .
Cat. No.: HY-P87359
Synonyms: ATP dependent helicase CHD 1 antibody; ATP-dependent helicase CHD1 antibody; CHD 1 antibody; CHD-1 antibody; CHD1 antibody; CHD1_HUMAN antibody; Chromodomain helicase DNA binding protein 1 antibody; Chromodomain-helicase-DNA-binding protein 1 antibody; DKFZp686E2337 antibody; OTTHUMP00000222625 antibody
Cat. No.: HY-RS17654
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Chd1l Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chd1l gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-183603
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FRC-222 is a CHD1 tandem chromodomain inhibitor with a Kd of 0.15 μM and an IC50 of 0.18 μM. FRC-222 binds to the H3K4me3 binding site of CHD1 tandem chromodomain via aromatic cage interactions and extended ligand contacts. FRC-222 can be used for the research of prostate cancer[1].
Cat. No.: HY-183602
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FRC-303 is a CHD1 inhibitor with a Kd of 0.14 μM and an IC50 of 0.18 μM. FRC-303 binds to the H3K4me3 binding site of CHD1 tandem chromodomain, forms aromatic cage interactions and extended ligand contacts, acts as a methyl-lysine mimic, and occupies natural peptide ligand-binding regions. FRC-303 can be used for the research of prostate cancer .
Cat. No.: HY-P71588
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CHD1L; Chromo Domain-Containing Protein 1-Like; Chromodomain Helicase DNA Binding Protein 1 Like; Amplified In Liver Cancer Protein 1; ALC1; Amplified In Liver Cancer 1; Chromodomain-Helicase-DNA-Binding Protein 1-Like; CHDL; ATP-Dependent Chromatin Remod
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
