CHD1 Antibody (YA7042)
(Synonyms: ATP dependent helicase CHD 1 antibody; ATP-dependent helicase CHD1 antibody; CHD 1 antibody; CHD-1 antibody; Chd1 antibody; CHD1_HUMAN antibody; Chromodomain helicase DNA binding protein 1 antibody; Chromodomain-helicase-DNA-binding protein 1 antibody; DKFZp686E2337 antibody; OTTHUMP00000222625 antibody)CHD1 Antibody (YA7042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHD1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 |
Product Details
CHD1 Antibody (YA7042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHD1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 260 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 197 kDa
Recombinant protein within Human CHD1 aa 1,479-1,710 / 1,710.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CHD1 is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells[1][2].
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Subcellular Localization
Nucleus,Cytoplasm
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Expression
Tissue_Specificity: Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia -
Isoforms & Post-Translational Modification
O14646 has two isomers: O14646-1: 196688 Da (predicted); O14646-2: 196590 Da (predicted).
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Subunit
Component of the SAGA complex (By similarity)
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SwissProt ID
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Synonyms
ATP dependent helicase CHD 1 antibody; ATP-dependent helicase CHD1 antibody; CHD 1 antibody; CHD-1 antibody; Chd1 antibody; CHD1_HUMAN antibody; Chromodomain helicase DNA binding protein 1 antibody; Chromodomain-helicase-DNA-binding protein 1 antibody; DKFZp686E2337 antibody; OTTHUMP00000222625 antibody
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