3041166-70-2
3041166-70-2
Chemical Structure
CHD-1
- CAS No.: 3041166-70-2
- Formula:C16H12FNO4
- Molecular Weight:301.27
InChIKey: OFOOHWAJXHWPNV-FNORWQNLSA-N
SMILES: FC1=CC(C(/C=C/C2=CC=CC([N+]([O-])=O)=C2)=O)=CC=C1OC
Biological Activity: CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo[1].
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CHD-1 | CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo. | |||||||||||||||||||||
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