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Cat. No.: HY-170565

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CHD-1

CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo.

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CAS No.: 3041166-70-2
화학식: C₁₆H₁₂FNO₄
분자량:301.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CHD-1 Chemical Structure

CAS No.: 3041166-70-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: CHD-1	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
HCT-116	IC₅₀	>50 μM Compound: CHD-1	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
HeLa	IC₅₀	>50 μM Compound: CHD-1	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
HepG2	IC₅₀	>50 μM Compound: CHD-1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
MCF7	IC₅₀	>100 μM Compound: CHD-1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]

Chemical Information

CAS No. 3041166-70-2
분자량 301.27
화학식 C₁₆H₁₂FNO₄
SMILES

FC1=CC(C(/C=C/C2=CC=CC([N+]([O-])=O)=C2)=O)=CC=C1OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang F, et al. Hypoxia-selective prodrug restrains tumor cells through triggering mitophagy and inducing apoptosis. Eur J Med Chem. 2025 Feb 5;283:117155. [Content Brief]

Calculators

몰농도 계산기

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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