CHD-1
CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo.
For research use only. We do not sell to patients.
- CAS No.: 3041166-70-2
- Formula: C16H12FNO4
- Molecular Weight:301.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: CHD-1
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs
|
[PMID: 36610249] |
| HCT-116 | IC50 |
>50 μM
Compound: CHD-1
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs
|
[PMID: 36610249] |
| HeLa | IC50 |
>50 μM
Compound: CHD-1
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs
|
[PMID: 36610249] |
| HepG2 | IC50 |
>50 μM
Compound: CHD-1
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs
|
[PMID: 36610249] |
| MCF7 | IC50 |
>100 μM
Compound: CHD-1
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs
|
[PMID: 36610249] |
Chemical Information
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CAS No. 3041166-70-2
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Molecular Weight 301.27
-
Formula C16H12FNO4
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SMILES
FC1=CC(C(/C=C/C2=CC=CC([N+]([O-])=O)=C2)=O)=CC=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)