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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
CREB-binding protein
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "CREB-binding protein" in MCE Product Catalog:
135
135 Publications Verification
Synonyms: Diferuloylmethane; Natural Yellow 3; Turmeric yellow
2
2 Cited Publications
Synonyms: Diferuloylmethane (Standard); Natural Yellow 3 (Standard); Turmeric yellow (Standard)
2
2 Cited Publications
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
EML425 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.
Cat. No.: HY-147868
CAS No.: 2447559-21-7
Research Areas:
DC-CPin711 is a potent and selective inhibitor of CREB-binding protein (CBP) bromodomain with an IC50 of 0.0626 μM. DC-CPin711 arrests cell cycle at G1 phase and induces apoptosis .
Cat. No.: HY-N0005S
CAS No.: 1246833-26-0
Synonyms: Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6
Research Areas:
Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP .
Target:
Research Areas:
Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis .
Cat. No.: HY-N0005S1
Synonyms: Diferuloylmethane-d3; Natural Yellow 3-d3; Turmeric yellow-d3
Cat. No.: HY-161958
Target:
Research Areas:
dCE-2 is a CBP/EP300 PROTAC degrader with a DC50 of 40 nM against CBP. dCE-2 forms a ternary complex with the bromodomains of CBP/EP300 and the CRBN E3 ligase, driving proteasomal degradation of CBP/EP300 via positive cooperativity. dCE-2 is applicable to research related to multiple myeloma, prostate cancer, and neuroblastoma .
Cat. No.: HY-147869
CAS No.: 893781-17-4
Research Areas:
DC-CPin7 is a potent inhibitor of CREB-binding protein (CBP) bromodomain with an IC50 of 2.5 μM .
Cat. No.: HY-177840
Target:
Research Areas:
Liposomal Curcumin is a specialized delivery system that encapsulates Curcumin (HY-N0005) within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
The product size below only indicate the effective content of Curcumin.
The product size below only indicate the effective content of Curcumin.
Cat. No.: HY-164520
CAS No.: 491828-75-2
PMED-1 is a β-catenin inhibitor that significantly reduces β-catenin activity in hepatoblastoma cells and various HCC cells, with an IC50 value ranging from 4.87 to 32 μM. PMED-1 affects Wnt signaling by decreasing the interaction between β-catenin and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research .
Cat. No.: HY-P702890
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CREBBP; CREB-binding protein; Prev. RSTS; CREB binding Lysine Acetyltransferase; CBP; Rubinstein-Taybi Syndrome; CREB binding protein; Histone Acetyltransferase; KAT3A; CREBBP protein; protein-Lysine Acetyltransferase CREBBP; RSTS1; Histone Lysine Acetylt
Cat. No.: HY-P702891
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CREBBP; CREB-binding protein; Prev. RSTS; CREB binding Lysine Acetyltransferase; CBP; Rubinstein-Taybi Syndrome; CREB binding protein; Histone Acetyltransferase; KAT3A; CREBBP protein; protein-Lysine Acetyltransferase CREBBP; RSTS1; Histone Lysine Acetylt
Cat. No.: HY-161960
Research Areas:
EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958) .
Cat. No.: HY-161250
Target:
Research Areas:
Pomalidomide-NH-PEG6-amide-C2-CPI-1612 is a CBP/EP300 PROTAC degrader with a DC50 value of 1.3 μM. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 mediates the formation of a ternary complex between CRBN and the core of CBP, with an EC50 of 1.2 μM. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 inhibits cancer cell growth and exhibits cell line-specific degradation activity. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 can be used in research related to multiple myeloma and leukemia .
Cat. No.: HY-P702959
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CREBBP; CREB-binding protein; Prev. RSTS; CREB binding Lysine Acetyltransferase; CBP; Rubinstein-Taybi Syndrome; CREB binding protein; Histone Acetyltransferase; KAT3A; CREBBP protein; protein-Lysine Acetyltransferase CREBBP; RSTS1; Histone Lysine Acetylt
Cat. No.: HY-110263R
CAS No.: 1675821-32-5
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
EML 425 (Standard) is the analytical standard of EML 425 (HY-110263). This product is intended for research and analytical applications. EML425 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
