491828-75-2
491828-75-2
Chemical Structure
PMED-1
- CAS No.: 491828-75-2
- Formula:C20H18FN3O
- Molecular Weight:335.37
InChIKey: NSIMIZBPCMJSGO-UHFFFAOYSA-N
SMILES: O=C(NC1=CN(CC2=CC=C(F)C=C2)N=C1)C(C3)C3C4=CC=CC=C4
Biological Activity: PMED-1 is a β-catenin inhibitor that significantly reduces β-catenin activity in hepatoblastoma cells and various HCC cells, with an IC50 value ranging from 4.87 to 32 μM. PMED-1 affects Wnt signaling by decreasing the interaction between β-catenin and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research[1].
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PMED-1 | PMED-1 is a β-catenin inhibitor that significantly reduces β-catenin activity in hepatoblastoma cells and various HCC cells, with an IC50 value ranging from 4.87 to 32 μM. PMED-1 affects Wnt signaling by decreasing the interaction between β-catenin and CREB binding protein, thereby inhibiting cell proliferation. PMED-1 has potential applications in cancer research. | |||||||||||||||||||||
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