1. Apoptosis
  2. MDM-2/p53
  3. MS7972

MS7972 

Cat. No.: HY-119053 Purity: 99.81%
Handling Instructions

MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM.

For research use only. We do not sell to patients.

MS7972 Chemical Structure

MS7972 Chemical Structure

CAS No. : 352553-42-5

Size Price Stock Quantity
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM[1].

In Vitro

Addition of MS7972 to the CBP BRD results in emission at 445 nm and quenching of the CBP BRD due to resonance energy transfer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

227.26

Formula

C₁₄H₁₃NO₂

CAS No.

352553-42-5

SMILES

O=C1C(N(C(C)=O)C2=C3C=CC=C2)=C3CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (440.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4002 mL 22.0012 mL 44.0025 mL
5 mM 0.8800 mL 4.4002 mL 8.8005 mL
10 mM 0.4400 mL 2.2001 mL 4.4002 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.00 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MS7972MS 7972MS-7972MDM-2/p53Inhibitorinhibitorinhibit

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MS7972
Cat. No.:
HY-119053
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