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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
CYP450 2D6
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "CYP450 2D6" in MCE Product Catalog:
Cat. No.: HY-N6023
CAS No.: 19993-32-9
Cat. No.: HY-178479
CAS No.: 2581050-29-3
Research Areas:
IDO1-IN-30 (Compound (R)-100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions .
Cat. No.: HY-W803860
CAS No.: 86383-21-3
Target:
Research Areas:
N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects .
Cat. No.: HY-178479A
Target:
Research Areas:
(Rac)-IDO1-IN-30 is the Rac isomer of IDO1-IN-30 (HY-178479). IDO1-IN-30 is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions .
Cat. No.: HY-117593
CAS No.: 1369591-04-7
Target:
Research Areas:
NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 (HY-19626), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes (IC50 > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers .
Cat. No.: HY-182908
CAS No.: 2892569-27-4
CXCR4-antagonist-12 is a CXCR4 antagonist with an IC50 of 78 nM. CXCR4-antagonist-12 is applicable to research on cancers with high CXCR4 expression .
Cat. No.: HY-182909
CAS No.: 2892568-27-1
CXCR4-antagonist-11 is a CXCR4 antagonist with CXCR4 IC50 values of 68.9 nM and 48.3 nM. CXCR4-antagonist-11 modulates CXCR4 receptor function. CXCR4-antagonist-11 demonstrates high permeability, selectivity against CYP 2D6, and a high hERG index. CXCR4-antagonist-11 shows improved oral exposure in mouse pharmacokinetic studies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
