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Capsaicinoid

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By Targets:	Drug Derivative (1) Environmental Pollutants (1) GABA Receptor (1) JNK (2) Keap1-Nrf2 (1) Reference Standards (3) TRP Channel (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W097899

Vanillylamine 1 Publications Verification	JNK	Cancer
Vanillylamine is an immediate precursor for capsaicinoids. Vanillylamine is a derivative of Vanillin (HY-N0098) is synthesized through a transaminase reaction in the phenylpropanoid pathway of capsaicinoid synthesis. Vanillylamine significantly alleviates myelosuppression caused by abdominal and pelvic tumor chemotherapy .

HY-N0449

Nordihydrocapsaicin	Environmental Pollutants Keap1-Nrf2 GABA Receptor	Metabolic Disease Cancer
Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed .

HY-N5082

Homodihydrocapsaicin I	Others	Others
Homodihydrocapsaicin I is a kind of capsaicinoid from the fruits of Capsicum annuum .

HY-N5099

N-Vanillyldecanamide	Others	Metabolic Disease
N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum, significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner .

HY-W712539

Homodihydrocapsaicin II	Drug Derivative	Neurological Disease Inflammation/Immunology
Homodihydrocapsaicin II is a capsaicinoid with analgesic and anti-inflammatory effects, which is found in capsicum fruits. Homodihydrocapsaicin II is promising for research of inflammatory diseases and neuropathic pain .

HY-N0449R

Nordihydrocapsaicin (Standard)	Reference Standards Others	Others
Nordihydrocapsaicin (Standard) is the analytical standard of Nordihydrocapsaicin. This product is intended for research and analytical applications. Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers .

HY-W097899R

Vanillylamine (Standard)	Reference Standards JNK	Cancer
Vanillylamine is an immediate precursor for capsaicinoids. Vanillylamine is a derivative of Vanillin (HY-N0098) is synthesized through a transaminase reaction in the phenylpropanoid pathway of capsaicinoid synthesis. Vanillylamine significantly alleviates myelosuppression caused by abdominal and pelvic tumor chemotherapy .

HY-N11950

N-Vanillyloctanamide	Others	Others
N-Vanillyloctanamide is a capsaicinoid that has the activity of inhibiting the root growth of plant seedlings. N-Vanillyloctanamide significantly reduces the root length of Lactuca sativa (seedling) in a dose-dependent manner .

HY-N11468

Homocapsaicin II	Others	Others
Homocapsaicin II is a pungent compound, that can be isolated from fruits of Capsicum annuum L .

HY-N5099R

N-Vanillyldecanamide (Standard)	Others Reference Standards	Metabolic Disease
N-Vanillyldecanamide (Standard) is the analytical standard of N-Vanillyldecanamide (HY-N5099). This product is intended for research and analytical applications. N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum, significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner .

HY-182517

AG1529	TRP Channel	Inflammation/Immunology
AG1529 is a TRPV1 inhibitor and capsaicinoid-based soft agent with a human TRPV1 IC₅₀ of 0.9-0.93 μM. AG1529 reversibly blocks capsaicin-evoked TRPV1 activation, binds to the TRPV1 capsaicin binding site, moderately affects pH-induced TRPV1 gating, and does not alter voltage- or heat-mediated TRPV1 responses. AG1529 suppresses TRPV1-mediated neuronal excitability, reduces capsaicin- and pH-evoked neuronal firing, abolishes histaminergic and inflammation-mediated TRPV1 sensitization. AG1529 exhibits anti-nociceptive and antipruritic effects, attenuates in vivo hyperalgesia and pruritus, dose-dependently reduces acute histaminergic itch in rodents, and mildly blocks hTRPA1 and hTRPM8 channel activity. AG1529 undergoes hydrolysis and dermal deactivation, minimizes TRPV1-associated side reactions, does not evoke capsaicin-like burning sensation, and does not disrupt physiological thermal regulation. AG1529 can be used for the research of inflammatory cutaneous nociception and acute histaminergic pruritus .

Vanillylamine 1 Publications Verification	Monophenols Capsicum annuum L. Classification of Application Fields Other Diseases Phenols Solanaceae Plants Disease Research Fields Source Classification	JNK
Vanillylamine is an immediate precursor for capsaicinoids. Vanillylamine is a derivative of Vanillin (HY-N0098) is synthesized through a transaminase reaction in the phenylpropanoid pathway of capsaicinoid synthesis. Vanillylamine significantly alleviates myelosuppression caused by abdominal and pelvic tumor chemotherapy .

Nordihydrocapsaicin	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Other Diseases Phenols Solanaceae Plants Disease Research Fields Source Classification	Environmental Pollutants Keap1-Nrf2 GABA Receptor
Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed .

Homodihydrocapsaicin I	Monophenols Capsicum annuum L. Classification of Application Fields Other Diseases Phenols Plants Solanaceae Disease Research Fields Source Classification	Others
Homodihydrocapsaicin I is a kind of capsaicinoid from the fruits of Capsicum annuum .

N-Vanillyldecanamide	Monophenols Capsicum annuum L. Classification of Application Fields Phenols Metabolic Disease Solanaceae Plants Disease Research Fields Source Classification	Others
N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum, significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner .

Homodihydrocapsaicin II	Structural Classification Monophenols Capsicum annuum L. Phenols Solanaceae Plants Source Classification	Drug Derivative
Homodihydrocapsaicin II is a capsaicinoid with analgesic and anti-inflammatory effects, which is found in capsicum fruits. Homodihydrocapsaicin II is promising for research of inflammatory diseases and neuropathic pain .

Nordihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Phenols Solanaceae Plants Source Classification	Reference Standards Others
Nordihydrocapsaicin (Standard) is the analytical standard of Nordihydrocapsaicin. This product is intended for research and analytical applications. Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers .

Vanillylamine (Standard)	Monophenols Capsicum annuum L. Phenols Solanaceae Plants Source Classification	Reference Standards JNK
Vanillylamine is an immediate precursor for capsaicinoids. Vanillylamine is a derivative of Vanillin (HY-N0098) is synthesized through a transaminase reaction in the phenylpropanoid pathway of capsaicinoid synthesis. Vanillylamine significantly alleviates myelosuppression caused by abdominal and pelvic tumor chemotherapy .

N-Vanillyloctanamide	Monophenols Capsicum annuum L. Phenols Solanaceae Plants Source Classification	Others
N-Vanillyloctanamide is a capsaicinoid that has the activity of inhibiting the root growth of plant seedlings. N-Vanillyloctanamide significantly reduces the root length of Lactuca sativa (seedling) in a dose-dependent manner .

Homocapsaicin II	Monophenols Capsicum annuum L. Phenols Plants Solanaceae Source Classification	Others
Homocapsaicin II is a pungent compound, that can be isolated from fruits of Capsicum annuum L .

N-Vanillyldecanamide (Standard)	Structural Classification Monophenols Capsicum annuum L. Phenols Solanaceae Plants Source Classification	Others Reference Standards
N-Vanillyldecanamide (Standard) is the analytical standard of N-Vanillyldecanamide (HY-N5099). This product is intended for research and analytical applications. N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum, significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Capsaicinoid

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