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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Capsaicinoid
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Capsaicinoid" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W097899
CAS No.: 1196-92-5
Category:
Capsicum annuum L. Monophenols Other Diseases Phenols Plants Solanaceae Disease Research Fields
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Cat. No.: HY-N0449
CAS No.: 28789-35-7
Cat. No.: HY-N5082
CAS No.: 20279-06-5
Category:
Capsicum annuum L. Monophenols Other Diseases Phenols Plants Solanaceae Disease Research Fields
Target:
Cat. No.: HY-N5099
CAS No.: 31078-36-1
Category:
Capsicum annuum L. Monophenols Metabolic Disease Phenols Plants Solanaceae Disease Research Fields
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Cat. No.: HY-W712539
CAS No.: 71239-21-9
Category:
Target:
Cat. No.: HY-N0449R
CAS No.: 28789-35-7
Target:
Cat. No.: HY-W097899R
CAS No.: 1196-92-5
Category:
Target:
Cat. No.: HY-N11950
CAS No.: 58493-47-3
Category:
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Cat. No.: HY-N11468
CAS No.: 71240-51-2
Category:
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Cat. No.: HY-N5099R
CAS No.: 31078-36-1
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Cat. No.: HY-182517
CAS No.: 2225980-49-2
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Research Areas:
AG1529 is a TRPV1 inhibitor and capsaicinoid-based soft agent with a human TRPV1 IC50 of 0.9-0.93 μM. AG1529 reversibly blocks capsaicin-evoked TRPV1 activation, binds to the TRPV1 capsaicin binding site, moderately affects pH-induced TRPV1 gating, and does not alter voltage- or heat-mediated TRPV1 responses. AG1529 suppresses TRPV1-mediated neuronal excitability, reduces capsaicin- and pH-evoked neuronal firing, abolishes histaminergic and inflammation-mediated TRPV1 sensitization. AG1529 exhibits anti-nociceptive and antipruritic effects, attenuates in vivo hyperalgesia and pruritus, dose-dependently reduces acute histaminergic itch in rodents, and mildly blocks hTRPA1 and hTRPM8 channel activity. AG1529 undergoes hydrolysis and dermal deactivation, minimizes TRPV1-associated side reactions, does not evoke capsaicin-like burning sensation, and does not disrupt physiological thermal regulation. AG1529 can be used for the research of inflammatory cutaneous nociception and acute histaminergic pruritus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
