Nordihydrocapsaicin

Name: Nordihydrocapsaicin
Brand: MedChemExpress
SKU: HY-N0449
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0449 Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers.

For research use only. We do not sell to patients.

Nordihydrocapsaicin Chemical Structure

CAS No. : 28789-35-7

Size	Price	Stock	Quantity
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers^[1].

Molecular Weight

293.40

Formula

C₁₇H₂₇NO₃

CAS No.

28789-35-7

Appearance

Solid

Color

Light brown to gray

SMILES

CC(C)CCCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Structure Classification

Alkaloids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (170.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4083 mL	17.0416 mL	34.0832 mL
5 mM	0.6817 mL	3.4083 mL	6.8166 mL
10 mM	0.3408 mL	1.7042 mL	3.4083 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (264 KB) SDS (393 KB)

COA (242 KB) HNMR (241 KB) LCMS (263 KB)

Handling Instructions (2659 KB)

References

[1]. Alvarez-Parrilla E, et al. Antioxidant activity of fresh and processed Jalapeño and Serrano peppers. J Agric Food Chem. 2011 Jan 12;59(1):163-73. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4083 mL	17.0416 mL	34.0832 mL	85.2079 mL
	5 mM	0.6817 mL	3.4083 mL	6.8166 mL	17.0416 mL
	10 mM	0.3408 mL	1.7042 mL	3.4083 mL	8.5208 mL
	15 mM	0.2272 mL	1.1361 mL	2.2722 mL	5.6805 mL
	20 mM	0.1704 mL	0.8521 mL	1.7042 mL	4.2604 mL
	25 mM	0.1363 mL	0.6817 mL	1.3633 mL	3.4083 mL
	30 mM	0.1136 mL	0.5681 mL	1.1361 mL	2.8403 mL
	40 mM	0.0852 mL	0.4260 mL	0.8521 mL	2.1302 mL
	50 mM	0.0682 mL	0.3408 mL	0.6817 mL	1.7042 mL
	60 mM	0.0568 mL	0.2840 mL	0.5681 mL	1.4201 mL
	80 mM	0.0426 mL	0.2130 mL	0.4260 mL	1.0651 mL
	100 mM	0.0341 mL	0.1704 mL	0.3408 mL	0.8521 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nordihydrocapsaicin28789-35-7OtherscapsaicinoidanalogcongenercapsaicinchilipeppersInhibitorinhibitorinhibit

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Nordihydrocapsaicin

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