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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
Carvedilol
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "Carvedilol" in MCE Product Catalog:
14
Target:
Research Areas:
Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .
14
14 Cited Publications
Cat. No.: HY-B0006A
CAS No.: 610309-89-2
Synonyms: BM 14190 phosphate hemihydrate
Target:
Research Areas:
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker . Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome .
Cat. No.: HY-B0006B
CAS No.: 95094-00-1
Synonyms: (S)-BM 14190
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Research Areas:
(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX) .
Synonyms: 4-Hydroxyphenyl Carvedilol; 4-HydroxyCarvedilol
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Research Areas:
4-Hydroxyphenyl Carvedilol, a metabolite of Carvedilol, is an active metabolite of Carvedilol (HY-B0006) and is produced via CYP2D6-mediated oxidation .
Cat. No.: HY-B0006C
CAS No.: 95093-99-5
Synonyms: (R)-BM 14190
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Research Areas:
(R)-Carvedilol ((R)-BM 14190) is the orally active R-isomer of Carvedilol (HY-B0006). (R)-Carvedilol has α-receptor blocking activity but no β-receptor blocking activity. (R)-Carvedilol inhibits spontaneous Ca 2+ waves. (R)-Carvedilol inhibits stress-induced ventricular tachycardia and delays the development of UV-induced skin tumors and reduces their malignancy .
Cat. No.: HY-B0006R
CAS No.: 72956-09-3
Synonyms: BM 14190 (Standard)
Research Areas:
Carvedilol (Standard) is the analytical standard of Carvedilol. This product is intended for research and analytical applications. Carvedilol (BM 14190) is a non-selective β/α-1 blocker . Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure . Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .
Cat. No.: HY-B0006S1
CAS No.: 1133705-56-2
Synonyms: BM 14190-d4
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Research Areas:
SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC50 value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .
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VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress .
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VK-II-36 is a carvedilol analog that suppresses sarcoplasmic reticulum Ca 2+release but does not block the β-receptor.VK-II-36 inhibits triggered activities evoked by both early and delayed after depolarizations .
Cat. No.: HY-137387
CAS No.: 114869-83-9
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Research Areas:
Carvedilol Glucuronide is the metabolite of Carvedilol (HY-B0006). Carvedilol (BM 14190) is an antagonist for β/α-1 adrenergic receptor. Carvedilol inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol is an antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .
Cat. No.: HY-Z7733
CAS No.: 72956-44-6
Synonyms: DesmethylCarvedilol; BM-14242
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Research Areas:
O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively) .
Cat. No.: HY-151002S
CAS No.: 2673270-31-8
Cat. No.: HY-12767S
CAS No.: 1261395-96-3
Synonyms: 4-HydroxyCarvedilol-d5
Cat. No.: HY-12767S1
Synonyms: 4-Hydroxyphenyl Carvedilol-d4; 4-HydroxyCarvedilol-d4
Cat. No.: HY-B0006S
CAS No.: 1020719-25-8
Cat. No.: HY-B0006S2
CAS No.: 929106-58-1
Synonyms: BM 14190-d5
Cat. No.: HY-B0006BS
CAS No.: 2747915-23-5
Synonyms: (S)-BM 14190-d4
Cat. No.: HY-B0006CS
CAS No.: 2747915-92-8
Synonyms: (R)-BM 14190-d4
Cat. No.: HY-B0006BR
CAS No.: 95094-00-1
Synonyms: (S)-BM 14190 (Standard)
Research Areas:
(S)-Carvedilol (Standard) is the analytical standard of (S)-Carvedilol. This product is intended for research and analytical applications.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
