10 Results for "

Cd19 Inhibitors

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "Cd19 Inhibitors" in MCE Product Catalog:

8
8 Publications Verification
Cat. No.: HY-15579
CAS No.: 745017-94-1
Purity:  99.92%
Synonyms: Monomethylauristatin F
Research Areas:  

Cancer

MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...
8
8 Publications Verification
Cat. No.: HY-15579A
CAS No.: 1415246-68-2
Purity:  99.93%
Synonyms: Monomethylauristatin F hydrochloride
Research Areas:  

Cancer

MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...
8
8 Publications Verification
Cat. No.: HY-15579B
CAS No.: 1799706-65-2
Purity:  99.59%
Synonyms: Monomethylauristatin F sodium
Research Areas:  

Cancer

MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...
Cat. No.: HY-P99761
CAS No.: 1690307-05-1
Synonyms: XmAb5871

Target:  

CD19 Apoptosis

Research Areas:  

Inflammation/Immunology

Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus .
loading...
    loading...
Cat. No.: HY-P99976

Target:  

CD19

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD19 Antibody (1D3) is an IgG2a antibody inhibitor targeting mouse CD19. Anti-Mouse CD19 Antibody (1D3) reduces CD19 expression levels on the surface of B cells. Anti-Mouse CD19 Antibody (1D3) inhibits the replication of peritoneal B-1a cells .
loading...
    loading...
Cat. No.: HY-15579G
CAS No.: 745017-94-1
Synonyms: Monomethylauristatin F (GMP)
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...
Cat. No.: HY-79254
CAS No.: 864238-20-0
Target:  

ADC Payloads

Research Areas:  

Cancer

MMAF intermediate 2 is an intermediate for the synthesis of MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...
Cat. No.: HY-P991900

Target:  

CD19

Research Areas:  

Inflammation/Immunology

LY3541860 is a selective anti-CD19 antibody that both binds human CD19 with high affinity and selectively binds human B cells (Kd values: 76.8 pM and 94.5 nM for humans and cynomolgus monkeys, respectively). LY3541860 inhibits CpG-induced CD69 expression (IC50 = 0.006 nM). LY3541860 exhibits potent B cell inhibitory activities. LY3541860 can inhibit both BCR- and TLR-induced human B cell activation. LY3541860 can be used for the research of autoimmune diseases .
loading...
    loading...
Cat. No.: HY-79253
CAS No.: 161485-82-1
Target:  

ADC Payloads

Research Areas:  

Cancer

MMAF intermediate 1 is an intermediate in the synthesis of MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...
Cat. No.: HY-15579BG
CAS No.: 1799706-65-2
Synonyms: Monomethylauristatin F sodium (GMP)
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .
loading...
    loading...