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Obexelimab

(Synonyms: XmAb5871)
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Based on 1 Customer Validation

Obexelimab (XmAb5871) is a humanized anti-CD19 antibody. Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus erythematosus.

For research use only. We do not sell to patients.

  • Purity: 99.99%
  • CAS No.: 1690307-05-1
  • Molecular Weight:147.24 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Obexelimab
  • Experimental Validation Results for Obexelimab
  • Experimental Validation Results for Obexelimab
  • Experimental Validation Results for Obexelimab
  • Obexelimab Chemical Structure
    Obexelimab Chemical Structure
CAS No.: 1690307-05-1
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD19 (red) with Obexelimab (HY-P99761). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized CD19 Protein, Human (HEK293, His, HY-P74330) can bind Obexelimab. The EC50 for this effect is 16.38 ng/mL.

  • 1/16

    Loaded Obexelimab on AHC2 biosensor, can bind CD19 Protein, Human (HEK293, His, HY-P74330) with an affinity constant of 1.556E-09 M as determined in BLI assay.

  • Obexelimab Chemical Structure
    1/16
  • Obexelimab
  • Flow Cytometry analysis of Raji cells labelling CD19 (red) with Obexelimab (HY-P99761). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized CD19 Protein, Human (HEK293, His, HY-P74330) can bind Obexelimab. The EC50 for this effect is 16.38 ng/mL.
  • Loaded Obexelimab on AHC2 biosensor, can bind CD19 Protein, Human (HEK293, His, HY-P74330) with an affinity constant of 1.556E-09 M as determined in BLI assay.