2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. MMAF intermediate 2

MMAF intermediate 2 is an intermediate for the synthesis of MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A.

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MMAF intermediate 2 Chemical Structure

MMAF intermediate 2 Chemical Structure

CAS No. : 864238-20-0

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MMAF intermediate 2 Related Antibodies

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Description

MMAF intermediate 2 is an intermediate for the synthesis of MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A[1].

Molecular Weight

384.90

Formula

C19H29ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(OC)=O)CC1=CC=CC=C1)[C@H](C)[C@@H](OC)[C@H]2NCCC2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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MMAF intermediate 2 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAF intermediate 2864238-20-0MMAF intermediate2MMAF intermediate-2ADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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