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DCAF16

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (2) Apoptosis (1) CDK (1) E1/E2/E3 Enzyme (6) Epigenetic Reader Domain (14) FKBP (3) Ligands for E3 Ligase (1) Molecular Glues (11) PARP (1) PROTACs (5) Small Interfering RNA (siRNA) (2) SWI/SNF Complex (1)
By Research Areas:	Cancer (23)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156828

MMH2	Molecular Glues Epigenetic Reader Domain	Cancer
MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4_BD2) .

HY-163638

BRD4 degrader-1	Epigenetic Reader Domain Molecular Glues E1/E2/E3 Enzyme	Cancer
BRD4 degrader-1 (Compound mL 1-50) is a relatively selective, monovalent and covalent BRD4 Molecular glue degrader. BRD4 degrader-1 induces degradation of both long and short isoforms of BRD4 by targeting *DCAF16* (an E3 ligase). BRD4 degrader-1 can be used in breast cancer research .

HY-153385

TMX1	Molecular Glues Epigenetic Reader Domain	Cancer
TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of *DCAF16* and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the *BRD4-TMX1-DCAF16* ternary complex, and promotes the ubiquitination of BRD4 via the CRL4_DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity .

HY-172615

AMPTX-1	Molecular Glues Epigenetic Reader Domain	Cancer
AMPTX-1 is a selective, orally active, covalent reversible BRD9 molecular glue degrader with a DC₅₀ of 0.05 nM. AMPTX-1 selectively recruits BRD9 to the E3 ligase *DCAF16. AMPTX-1 forms a ternary complex with BRD9* and a reversible covalent adduct with Cys58 on the surface of *DCAF16. AMPTX-1 mediates BRD9* degradation via the proteasome and Cullin RING E3 ligase pathways. AMPTX-1 can be used in the research of solid tumors and hematological malignancies .

HY-156827

MMH1	Molecular Glues Epigenetic Reader Domain	Cancer
MMH1 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4_BD2) .

HY-129610

KB02-SLF	PROTACs FKBP	Cancer
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying *DCAF16* (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF .

HY-160528

IBG3 1 Publications Verification	Epigenetic Reader Domain Molecular Glues	Cancer
IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC₅₀ values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia .

HY-129917

KB02-JQ1 4 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying *DCAF16* (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1 .

HY-175756

SMARCA2/4 degrader-1	Molecular Glues SWI/SNF Complex	Cancer
SMARCA2/4 degrader-1 is a SMARCA2/4 molecular glue degrader with a DCAF16 EC₅₀ of 110 nM. SMARCA2/4 degrader-1 covalently adducts at cysteine to form a ternary complex with SMARCA2/4 and recruits CUL4 ^DCAF16 and CRL1 ^FBXO22 E3 ligase complexes. SMARCA2/4 degrader-1 induces ubiquitination and proteasomal degradation of SMARCA2/4. SMARCA2/4 degrader-1 can be used for research of SMARCA4-deficient malignancies, non-small cell lung cancer (NSCLC), and colorectal cancer .

HY-163641

AR Degrader-1	Molecular Glues Androgen Receptor E1/E2/E3 Enzyme	Cancer
AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells .

HY-RS03562

DCAF16 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DCAF16 Human Pre-designed siRNA Set A contains three designed siRNAs for DCAF16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DCAF16 Human Pre-designed siRNA Set A DCAF16 Human Pre-designed siRNA Set A

HY-175187

LO-3-63	CDK E1/E2/E3 Enzyme	Cancer
LO-3-63, a Ribociclib (HY-15777) analog bearing a truncated fumaramide handle, is a PROTAC-like CDK4/6 degrader. LO-3-63 induces CUL4 ^DCAF16-dependent degradation of CDK4/6 in cells .

HY-RS23600

Dcaf16 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dcaf16 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dcaf16 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dcaf16 Rat Pre-designed siRNA Set A Dcaf16 Rat Pre-designed siRNA Set A

HY-157592

MMH2-NR	Molecular Glues Epigenetic Reader Domain	Cancer
MMH2-NR a negtive control of MMH2. MMH2 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader .

HY-176070

HRG038	Epigenetic Reader Domain	Cancer
HRG038 is a selective covalent BRD4 degrader. HRG038 binds covalently to the E3 ubiquitin ligase CUL4 DCAF16, recruiting it to BRD4, leading to the ubiquitination and subsequent proteasomal degradation of BRD4. HRG038 is promising for research of cancers .

HY-170983

MC-25B	FKBP	Cancer
MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC₅₀ of 0.35 μM and a D_max of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. (Pink: FKBP12 ligand (HY-170988); Blue: E3 ligase ligand HY-170986); Black: linker (HY-128844); FKBP12 ligand+ linker (HY-170987)) .

HY-147196

KB03-SLF	PROTACs FKBP	Cancer
KB03-SLF (compound 6) is an electrophilic PROTAC degrader that binds to DCAF16 to degrade the nuclear protein FKBP12. KB03-SLF can be used in cancer research . (Pink: Ligand for target protein SLF (HY-114872); Black: Linker (HY-W040168); Blue: Ligand for E3 ligase (HY-169968)).

HY-176067

LO-4-25	Androgen Receptor	Cancer
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its truncated variant AR-V7. LO-4-25 covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, promoting the ubiquitination of AR and AR-V7, which subsequently are recognized and degraded by the proteasome, reducing the protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research of androgen-independent prostate cancers .

HY-157591

MMH1-NR	Molecular Glues Epigenetic Reader Domain	Cancer
MMH1-NR, containing a non-reactive (ethyl) group is a negative control of MMH1. MMH1 is a CUL4-associated factor (DCAF16)-based bromodomain protein 4 (BRD4) degrader .

HY-169968

E3 ligase Ligand 41	Ligands for E3 Ligase E1/E2/E3 Enzyme	Cancer
E3 ligase Ligand 41 (Compound SI-13) is a ligand for E3 ubiquitin ligase DCAF16. E3 ligase Ligand 41 can be connected to SLF (HY-114872) by a linker (HY-W040168) to form KB03-SLF (HY-147196) .

HY-175186

LO-3-62	Epigenetic Reader Domain E1/E2/E3 Enzyme	Cancer
LO-3-62 is a PROTAC-like SMARCA2/4 degrader with a truncated fumaramide handle. LO-3-62 degrades SMARCA2/4 in cells .

HY-175179

LO-3-61	Epigenetic Reader Domain E1/E2/E3 Enzyme	Cancer
LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells .

HY-183575

JQ1-JX5	PROTACs Epigenetic Reader Domain	Cancer
JQ1-JX5 is a DCAF16-based BRD4 PROTAC degrader. JQ1-JX5 covalently modifies Cys58 of DCAF16, promotes ternary complex formation with BRD4, enables BRD4 ubiquitination and proteasomal degradation. JQ1-JX5 induces time-dependent degradation of BRD4 long and short isoforms in AGS cells with DC₅₀ of 43.97 and 16.77 nM. JQ1-JX5 can be used for the research of cancer, such as acute myeloid leukemia .

HY-182766

AMX-883	Molecular Glues Epigenetic Reader Domain	Cancer
AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML) .

HY-183013

PROTAC PARP2 degrader-1	PROTACs PARP Apoptosis	Cancer
PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC₅₀ of 2 μM. PROTAC PARP2 degrader-1 potently inhibits the enzymatic activities of PARP1 (IC₅₀ = 2.74 nM) and PARP2 (IC₅₀ = 0.32 nM), with approximately 10-fold higher selectivity for PARP2. PROTAC PARP2 degrader-1 induces cell cycle arrest and apoptosis, and exhibits significant anti-tumor efficacy in mouse models. PROTAC PARP2 degrader-1 can be used for the research of triple-negative breast cancer .

Species:	Human (4)
Tag:	His (1) Tag Free (3)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701517

	DCAF16 Protein, Human (sf9) DCAF16; DDB1- and CUL4-associated factor 16	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16 Protein, Human (sf9) is the recombinant human-derived DCAF16 protein, expressed by sf9 insect cells , with tag free.

HY-P701518

	DCAF16 Protein, Human (sf9, His) DCAF16; DDB1- and CUL4-associated factor 16	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16 Protein, Human (sf9, His) is the recombinant human-derived DCAF16 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

HY-P703472

	DCAF16-DDB1 Protein, Human (Active, Biotinylated, sf9) C4orf30	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16/DDB1 Protein, Human (Active, Biotinylated, sf9) is the recombinant human-derived DCAF16/DDB1, expressed by Sf9 insect cells, with tag-free.

HY-P703559

	DCAF16-DDB1-CUL4A-RBX1 Protein, Human (sf9) C4orf30	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16/DDB1/CUL4A/RBX1 Protein, Human (Sf9) is the recombinant human-derived DCAF16/DDB1/CUL4A/RBX1, expressed by Sf9 insect cells, with tag-free.

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DCAF16 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DCAF16 Human Pre-designed siRNA Set A contains three designed siRNAs for DCAF16 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dcaf16 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dcaf16 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dcaf16 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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