2384184-40-9
Chemical Structure
KB02-SLF
- CAS No.: 2384184-40-9
- Formula:C50H65ClN4O12
- Molecular Weight:949.52
IUPAC Name: (R)-1-(3-(3-(2-(2-(2-((1-(2-chloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl)oxy)acetamido)ethoxy)ethoxy)propanamido)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
InChIKey: OKJBKEQXKMMRPL-WVILEFPPSA-N
SMILES: O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(COC3=CC4=C(N(C(CCl)=O)CCC4)C=C3)=O)=O)=C2)CCC5=CC=C(OC)C(OC)=C5
Biological Activity: KB02-SLF is a nuclear FKBP12 covalent PROTAC degrader. KB02-SLF covalently modifies cysteine residues in DCAF16, forms a ternary complex with nuclear FKBP12, and mediates degradation via the CUL4-DDB1 E3 ubiquitin ligase pathway. KB02-SLF promotes polyubiquitination and proteasomal degradation of nucleus-localized FKBP12. KB02-SLF can be used in breast cancer research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KB02-SLF | 99.25% | KB02-SLF is a nuclear FKBP12 covalent PROTAC degrader. KB02-SLF covalently modifies cysteine residues in DCAF16, forms a ternary complex with nuclear FKBP12, and mediates degradation via the CUL4-DDB1 E3 ubiquitin ligase pathway. KB02-SLF promotes polyubiquitination and proteasomal degradation of nucleus-localized FKBP12. KB02-SLF can be used in breast cancer research. | ||||||||||||||||||||
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-
Similarity Score 0.72
HY-147196KB03-SLF -
Similarity Score 0.66
HY-170987FKBP12 Ligand-Linker Conjugate 1 -
Similarity Score 0.65
HY-103634dFKBP-1 -
Similarity Score 0.65
HY-107452SLF-amido-C2-COOH -
Similarity Score 0.65
HY-150410TSPO ligand-3 -
Similarity Score 0.64
HY-17308210-SLF -
Similarity Score 0.59
HY-170988FKBP12 ligand-1 -
Similarity Score 0.59
HY-148509PhosTAC5 -
Similarity Score 0.58
HY-126316Zapalog -
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