2384184-42-1
Chemical Structure
KB03-SLF
- CAS No.: 2384184-42-1
- Formula:C50H63ClF3N5O12
- Molecular Weight:1018.51
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6-bromo-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
InChIKey: JXTWMUOLYMSLIA-ZESVVUHVSA-N
SMILES: O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@@H](C2=CC(NC(CCOCCOCCNC(CCNC(C3=CC(NC(CCl)=O)=CC(C(F)(F)F)=C3)=O)=O)=O)=CC=C2)CCC4=CC(OC)=C(C=C4)OC
Biological Activity: KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12NLS. KB03-SLF fails to degrade nuclear-localized FKBP12NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12NLS in a manner similar to KB02-SLF (HY-129610)[1].
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KB03-SLF | KB03-SLF is a bifunctional PROTAC, formed by conjugating the cysteine-targeting KB03 exploratory fragment with SLF (HY-114872), an FKBP12 ligand that does not support the degradation of FKBP12NLS. KB03-SLF fails to degrade nuclear-localized FKBP12NLS in cells, nor can it mediate the interaction between DCAF16 and FKBP12NLS in a manner similar to KB02-SLF (HY-129610). | |||||||||||||||||||||
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Keywords
