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Results for "

DHCR7

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107420
    AY 9944
    5+ Cited Publications

    		 Endogenous Metabolite Metabolic Disease
    AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .
    AY 9944
  • HY-164561
    TASIN-30
    1 Publications Verification

    		 Emopamil Binding Protein Ferroptosis Apoptosis Cancer
    TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma .
    TASIN-30
  • HY-Y0889A
    1-(2,3-Dichlorphenyl)piperazine hydrochloride

    		Endogenous Metabolite Metabolic Disease
    1-(2,3-Dichlorphenyl)piperazine hydrochloride is a potent DHCR7 inhibitor with the activity of inhibiting cholesterol biosynthesis. 1-(2,3-Dichlorphenyl)piperazine hydrochloride is often used in biological research to evaluate the function of cholesterol biosynthesis pathway. The application of 1-(2,3-Dichlorphenyl)piperazine hydrochloride is of great significance for understanding diseases related to cholesterol biosynthesis .
    1-(2,3-Dichlorphenyl)piperazine hydrochloride
  • HY-RS03727
    DHCR7 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DHCR7 Human Pre-designed siRNA Set A contains three designed siRNAs for DHCR7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DHCR7 Human Pre-designed siRNA Set A
    DHCR7 Human Pre-designed siRNA Set A
  • HY-RS17300
    Dhcr7 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dhcr7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dhcr7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dhcr7 Mouse Pre-designed siRNA Set A
    Dhcr7 Mouse Pre-designed siRNA Set A
  • HY-RS23755
    Dhcr7 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dhcr7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dhcr7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dhcr7 Rat Pre-designed siRNA Set A
    Dhcr7 Rat Pre-designed siRNA Set A
  • HY-Y0889
    1-(2,3-Dichlorphenyl)piperazine

    		Endogenous Metabolite Metabolic Disease
    1-(2,3-Dichlorphenyl)piperazine is a potent DHCR7 inhibitor with the activity of inhibiting cholesterol biosynthesis. 1-(2,3-Dichlorphenyl)piperazine is often used in biological research to evaluate the function of cholesterol biosynthesis pathway. The application of 1-(2,3-Dichlorphenyl)piperazine is of great significance for understanding diseases related to cholesterol biosynthesis .
    1-(2,3-Dichlorphenyl)piperazine
  • HY-107420R
    AY 9944 (Standard)

    		Endogenous Metabolite Reference Standards Metabolic Disease
    AY 9944 (Standard) is the analytical standard of AY 9944 (HY-107420). This product is intended for research and analytical applications. AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .
    AY 9944 (Standard)

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