1678515-93-9
Chemical Structure
TASIN-30
- CAS No.: 1678515-93-9
- Formula:C18H30N2O3S
- Molecular Weight:354.51
InChIKey: KWHTXYFUJIBRNB-UHFFFAOYSA-N
SMILES: O=S(C1=C(C)C=C(C)C=C1C)(N2CCC(CC2)NCCC(C)O)=O
Biological Activity: TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma[1][2][3].
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TASIN-30 | 99.96% | TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma. | ||||||||||||||||||||
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References
- [1]. Theodoropoulos PC, et al. A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins. J Am Chem Soc. 2020 Apr 1;142(13):6128-6138. [Content Brief]
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[2]. Jun Zhu, et al. TASIN-30-loaded Fe single-atom nanozyme disrupts 7-dehydrocholesterol
biosynthesis for enhanced tumor therapy. Chemical Engineering Journal Volume 532, 15 March 2026, 174161. - [3]. Li Y, et al. 7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature. 2024;626(7998):411-418. [Content Brief]
