41202-77-1
Chemical Structure
1-(2,3-Dichlorphenyl)piperazine
Synonym(s): 2,3-DCPP
- CAS No.: 41202-77-1
- Formula:C10H12Cl2N2
- Molecular Weight:231.12
IUPAC Name: 1-(2,3-dichlorophenyl)piperazine
InChIKey: UDQMXYJSNNCRAS-UHFFFAOYSA-N
SMILES: ClC1=C(Cl)C(N2CCNCC2)=CC=C1
Biological Activity: 1-(2,3-Dichlorophenyl) piperazine (2,3-DCPP) is a blood-brain barrier-permeable DHCR7 inhibitor. 1-(2,3-Dichlorophenyl) piperazine inhibits terminal cholesterol biosynthesis, leading to accumulation of 7-dehydrocholesterol and reduced cholesterol production. 1-(2,3-Dichlorophenyl) piperazine is a minor cytochrome P450 metabolite and exhibits dopamine D2/D3 receptor binding affinity[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-(2,3-Dichlorphenyl)piperazine | 99.38% | 1-(2,3-Dichlorophenyl) piperazine (2,3-DCPP) is a blood-brain barrier-permeable DHCR7 inhibitor. 1-(2,3-Dichlorophenyl) piperazine inhibits terminal cholesterol biosynthesis, leading to accumulation of 7-dehydrocholesterol and reduced cholesterol production. 1-(2,3-Dichlorophenyl) piperazine is a minor cytochrome P450 metabolite and exhibits dopamine D2/D3 receptor binding affinity. | ||||||||||||||||||||
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Similarity Score 0.97
HY-Y0889A1-(2,3-Dichlorphenyl)piperazine hydrochloride -
Similarity Score 0.94
HY-Z11110Aripiprazole impurity 28 -
Similarity Score 0.91
HY-W027787Aripiprazole impurity 9 -
Similarity Score 0.84
HY-W3514281-(3-Chloro-4-fluorophenyl)piperazine hydrochloride -
Similarity Score 0.83
HY-W0047581-(4-Chlorophenyl)piperazine -
Similarity Score 0.80
HY-W7150441-(2-Fluorophenyl)piperazine hydrochloride -
Similarity Score 0.79
HY-W012179Phenylpiperazine hydrochloride -
Similarity Score 0.79
HY-78240RPhenylpiperazine (Standard) -
Similarity Score 0.79
HY-W0096811-(2-Methoxyphenyl)piperazine hydrochloride -
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References
- [1]. Rmandić M, et al. Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC-MS/MS: Application to Clinical Practice. Molecules. 2022 Jul 31;27(15):4899. [Content Brief]
- [2]. Robarge MJ, et al. Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype. J Med Chem. 2001 Sep 13;44(19):3175-86.
- [3]. Genaro-Mattos TC, et al. Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis. Toxicology and applied pharmacology. 2018 Jun 15;349:21-28.
- [4]. Colovic M, et al. The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients. Pharmacologyonline. 2006;2:252-260.
