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Results for "

DMPK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Antibody-Oligonucleotide Conjugates (AOCs) (2) Biochemical Assay Reagents (1) EGFR (1) Endogenous Metabolite (1) FLAP (1) mGluR (2) SARS-CoV (1) Ser/Thr Kinase (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (4)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) siRNA drugs (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (4)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129550

BI-4020	EGFR	Cancer
BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. BI-4020 inhibits not only the triple mutant EGFR del19 T790M C797S variant (IC₅₀=0.2 nM in BaF3 cell lines) but also the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC₅₀=1 nM). BI-4020 also shows activity against EGFR wt (IC₅₀=190 nM). BI-4020 shows high kinome selectivity and good DMPK properties .

HY-145725A

Baliforsen ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx	Ser/Thr Kinase	Neurological Disease
Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits *DMPK* mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 .

HY-177454

Basivarsen linker	ADC Linker	Others
Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab (HY-P990780 Zeleciment) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

HY-118179

VU0486321	mGluR	Neurological Disease
VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

HY-12995A

(S)-BI 665915	FLAP	Inflammation/Immunology
(S)-BI 665915 is an orally active oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.7 nM for FLAP binding. (S)-BI 665915 inhibits FLAP functional in human whole blood with an IC₅₀ of 45 nM. (S)-BI 665915 demonstrates an excellent cross-species agent metabolism and pharmacokinetics (DMPK) profile and a dose-dependent inhibition of LTB₄ production .

HY-RS17187

Dmpk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dmpk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dmpk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dmpk Mouse Pre-designed siRNA Set A Dmpk Mouse Pre-designed siRNA Set A

HY-RS03827

DMPK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DMPK Human Pre-designed siRNA Set A contains three designed siRNAs for DMPK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DMPK Human Pre-designed siRNA Set A DMPK Human Pre-designed siRNA Set A

HY-16636

ML337	mGluR	Neurological Disease
ML337 is a selective and brain-penetrant negative allosteric modulator of mGlu3, with an IC₅₀ of 593 nM. ML337 possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile . ML337 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119185

AZD-6605	Endogenous Metabolite	Cancer
AZD-6605 is a potent, reversible inhibitor of MMP2, MMP9, MMP12 and MMP13 with excellent selectivity. During drug development, AZD-6605 was optimized for activity, solubility and DMPK properties against MMP13 by replacing the zinc hydroxide binding group associated with historical inhibitors .

HY-155527

SARS-CoV-2 Mpro-IN-9	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent SARS-CoV-2 M ^pro inhibitor (IC₅₀=0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication (EC₅₀=1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects (CC₅₀>50 μM) .

HY-RS23638

Dmpk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dmpk Rat Pre-designed siRNA Set A contains three designed siRNAs for Dmpk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dmpk Rat Pre-designed siRNA Set A Dmpk Rat Pre-designed siRNA Set A

HY-186089

Bis-Mal-Lysine-PEG4-DBCO	Antibody-Oligonucleotide Conjugates (AOCs)	Others
Bis-Mal-Lysine-PEG4-DBCO (CGBS-13) is a linker for AOC drugs and can be used to synthesize AOC drugs that inhibit *DMPK* gene expression .

HY-W800844

NH-bis(PEG8-OH)	Biochemical Assay Reagents	Others
NH-bis(PEG8-OH) is a homobifunctional reagent containing two alcohols joined together by a secondary amine. The alcohols can be used in a variety of ways such as in forming esters with carboxylic acids, while the secondary amine can be used as a nucleophile in linking with ketones, aldehydes, and carboxylic acids. The PEG spacers make this molecule water-soluble, potentially altering its DMPK properties.

HY-147262

Etedesiran	Antibody-Oligonucleotide Conjugates (AOCs) Small Interfering RNA (siRNA)	Neurological Disease
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .

Recombinant Proteins Recommended:

DMPK

Species:	Human (5)
Tag:	His (2) Tag Free (1) Strep (1) GST (3)
Source:	sf9 insect cells (1) Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70844

	HSPB2 Protein, Human (His) Heat shock protein beta-2; HspB2; DMPK-binding protein; MKBP	Human	E. coli
	HSPB2 Protein potentially regulates the kinase DMPK, enhancing its activity and influencing cellular processes. The specific mechanisms and broader implications in cellular signaling pathways require elucidation. Comprehensive studies are essential to unravel the precise molecular pathways and functional significance of the HSPB2-DMPK interplay, shedding light on its potential contributions to cellular regulation and signaling cascades. HSPB2 Protein, Human (His) is the recombinant human-derived HSPB2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P702635

	MRCKβ Protein, Human (sf9, GST) CDC42BPB; CDC42 binding protein kinase beta (DMPK-like); MRCKB; KIAA1124; CDC42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Serine/threonine-protein kinase MRCK beta	Human	Sf9 insect cells
	CDC42BPB protein is a key serine/threonine protein kinase downstream of CDC42 that controls cytoskeletal dynamics and cell migration. CDC42BPB phosphorylates PPP1R12C and MYL9/MLC2, regulates actin reorganization and shapes cell dynamics. MRCKβ Protein, Human (sf9, GST) is the recombinant human-derived MRCKβ, expressed by Sf9 insect cells, with GST labeled tag.

HY-P705758

	MRCKβ Protein, Human (Active, sf9, His-StrepII-GST) CDC42BPB; CDC42 binding protein kinase beta (DMPK-like); MRCKB; KIAA1124; CDC42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; MRCK beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Serine/threonine-protein kinase MRCK beta	Human	sf9 insect cells

HY-P702634

	MRCKG Protein, Human (Active, sf9) CDC42BPG; CDC42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase MRCK gamma; DMPK2; HSMDPKIN; kappa 200; MRCKgamma; MRCK gamma; DMPK-like gamma; CDC42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCKG; KAPPA-200	Human	Sf9 insect cells
	MRCKG Protein, Human (sf9) is the recombinant human-derived MRCKG, expressed by Sf9 insect cells , with tag Free labeled tag. ,

HY-P701817

	MRCKα Protein, Human (Active, sf9, GST) CDC42BPA; Serine/threonine-protein kinase MRCK alpha; CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; Myotonic dystrophy protein kinase-like alpha	Human	Sf9 insect cells
	The MRCKα protein is a key serine/threonine protein kinase downstream of CDC42 that coordinates cytoskeletal dynamics and cell migration. MRCKα phosphorylates PPP1R12C and MYL9/MLC2, regulating actin reorganization. MRCKα Protein, Human (sf9, GST) is the recombinant human-derived MRCKα protein, expressed by sf9 insect cells , with N-GST labeled tag.

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HY-P810142

	DMPK Antibody (YA9486)	WB, IP, ELISA	human
	DMPK Antibody (YA9486) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DMPK.

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Cat. No.	Product Name		Classification

HY-186089

Bis-Mal-Lysine-PEG4-DBCO		DBCO
Bis-Mal-Lysine-PEG4-DBCO (CGBS-13) is a linker for AOC drugs and can be used to synthesize AOC drugs that inhibit *DMPK* gene expression .

Cat. No.	Product Name		Classification

HY-145725A

Baliforsen ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx		Antisense Oligonucleotides
Baliforsen (ISIS 5987690) is an antisense oligonucleotide (ASO) that inhibits *DMPK* mRNA. Baliforsen binds within exon 9 of the human DMPK transcript to promote RNase H1-mediated degradation Baliforsen can be used for the research of myotonic dystrophy type 1 .

HY-145725

Baliforsen sodium IONIS 598769 sodium; ISIS 598769 sodium		Antisense Oligonucleotides
Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

HY-RS17187

Dmpk Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dmpk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dmpk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03827

DMPK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DMPK Human Pre-designed siRNA Set A contains three designed siRNAs for DMPK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23638

Dmpk Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Dmpk Rat Pre-designed siRNA Set A contains three designed siRNAs for Dmpk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-147262

Etedesiran		siRNAs siRNA drugs
Etedesiran is a component of the AOC drug Delpacibart etedesiran (HY-177565), formed by the reaction of an siRNA that induces cleavage of mRNA encoding myotonic dystrophy protein kinase (MTPK or DMPK) with SMCC linker (HY-42360). Etedesiran carries a maleimide group at its terminus, which can react with cysteine or lysine and is used for the synthesis of AOC drugs. Etedesiran is applicable to research related to myotonic dystrophy type 1 .

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