893556-15-5
Chemical Structure
AZD-6605
- CAS No.: 893556-15-5
- Formula:C18H21F4N3O6S
- Molecular Weight:483.43
IUPAC Name: (S)-5-methyl-5-(((4-(4-(1,1,2,2-tetrafluoroethoxy)phenoxy)piperidin-1-yl)sulfonyl)methyl)imidazolidine-2,4-dione
InChIKey: SBVAXUGOISPYPX-QGZVFWFLSA-N
SMILES: O=C1NC([C@](C)(N1)CS(=O)(N2CCC(CC2)OC3=CC=C(C=C3)OC(F)(C(F)F)F)=O)=O
Biological Activity: AZD-6605 is a potent, reversible inhibitor of MMP2, MMP9, MMP12 and MMP13 with excellent selectivity. During drug development, AZD-6605 was optimized for activity, solubility and DMPK properties against MMP13 by replacing the zinc hydroxide binding group associated with historical inhibitors[1].
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AZD-6605 | AZD-6605 is a potent, reversible inhibitor of MMP2, MMP9, MMP12 and MMP13 with excellent selectivity. During drug development, AZD-6605 was optimized for activity, solubility and DMPK properties against MMP13 by replacing the zinc hydroxide binding group associated with historical inhibitors. | |||||||||||||||||||||
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Keywords
