1560968-49-1
Chemical Structure
ML399
- CAS No.: 1560968-49-1
- Formula:C27H28FN3O2
- Molecular Weight:445.53
IUPAC Name: (R)-4-(3-(4-((3-fluorophenyl)(hydroxy)(pyridin-2-yl)methyl)piperidin-1-yl)propoxy)benzonitrile
InChIKey: YLADDJNCJBCBJE-HHHXNRCGSA-N
SMILES: O[C@@](C1CCN(CC1)CCCOC2=CC=C(C=C2)C#N)(C3=CC=CC=N3)C4=CC(F)=CC=C4
Biological Activity: ML399 is a Menin-MLL1 protein-protein interaction inhibitor with an IC50 of 90 nM. ML399 inhibits the proliferation of transformed mouse bone marrow cells. ML399 binds to the hERG potassium channel, exhibits superior in vitro physicochemical, drug metabolism and pharmacokinetic (DMPK) parameters, and has an extended half-life in rodents. ML399 can be used for research on acute myeloid leukemia and acute lymphoblastic leukemia[1].
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ML399 | ML399 is a Menin-MLL1 protein-protein interaction inhibitor with an IC50 of 90 nM. ML399 inhibits the proliferation of transformed mouse bone marrow cells. ML399 binds to the hERG potassium channel, exhibits superior in vitro physicochemical, drug metabolism and pharmacokinetic (DMPK) parameters, and has an extended half-life in rodents. ML399 can be used for research on acute myeloid leukemia and acute lymphoblastic leukemia. | |||||||||||||||||||||
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Keywords
