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FOXO1a

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By Targets:	FOXO (1) Akt (1) Apoptosis (1) DAPK (1) Drug Derivative (1) Isocitrate Dehydrogenase (IDH) (1) Mitochondrial Metabolism (1) Mitophagy (1) Nuclear Hormone Receptor 4A/NR4A (1) PDK-1 (1) PERK (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Antibodies

Oligonucleotides

Targets Recommended: FOXO

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases *PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1* proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and *IDH1, induces markers of ER stress (CHOP, ATF4* and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research ^[1] .

HY-16461

Solenopsin (-)-Solenopsin A	Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cardiovascular Disease
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective *Akt-1* inhibitor with an IC₅₀ of 5-10 μM, and also acts as an *RSK1* inhibitor. Solenopsin inhibits the activities of *PDK1* in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of *FOXO1a. Solenopsin induces Mitophagy* and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases ^[1] .

HY-RS05069

FOXO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FOXO1 Human Pre-designed siRNA Set A FOXO1 Human Pre-designed siRNA Set A

HY-RS22991

Foxo1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Foxo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo1 Rat Pre-designed siRNA Set A Foxo1 Rat Pre-designed siRNA Set A

HY-RS16559

Foxo1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Foxo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo1 Mouse Pre-designed siRNA Set A Foxo1 Mouse Pre-designed siRNA Set A

HY-N13285

(-)-Epigallocatechin-4'-O-methylether (-)-EGC-4'-O-ME	Drug Derivative	Metabolic Disease Inflammation/Immunology
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N13285

(-)-Epigallocatechin-4'-O-methylether (-)-EGC-4'-O-ME	Structural Classification Ouratea Aubl. Phenols Polyphenols Plants Source Classification	Drug Derivative
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury ^[1] .

Host:	Mouse (2) Rabbit (6)
Reactivity:	Human (8) Rat (1) Mouse (5)
Application:	IHC-P (5) ICC/IF (7) IP (1) IHC-F (3) WB (8) FC (1) ELISA (2)
Isotype:	IgG (6)
Conjugation:	Non-conjugated (8)
Clonality:	Polyclonal (1) Monoclonal (5) Recombinant (2)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80132

	FOXO1A Antibody (YA429)	WB, ICC/IF, IHC-P	Human, Mouse
	FOXO1A Antibody (YA429) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1A.

HY-P81074

	FOXO1/FOXO1A Antibody FOXO1; FKHR; FOXO1a; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat
	FOXO1/FOXO1A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to FOXO1/FOXO1A.

HY-P85429

	FoxO1 Antibody (YA5121) FOXO1; FKHR; FOXO1a; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma	WB, ICC/IF	Human, Mouse
	FoxO1 Antibody (YA5121) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FoxO1.

HY-P86588

	FOXO1 Antibody (YA6280) FOXO1; FKHR; FOXO1a; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	FOXO1 Antibody (YA6280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1.

HY-P80676

	FOXO1/FOXO1A Antibody (YA430) FOXO1; FKHR; FOXO1a; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1/FOXO1A Antibody (YA430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1/FOXO1A.

HY-P80676A

	FOXO1/FOXO1A Antibody (YA430)(PBS only) FOXO1; FKHR; FOXO1a; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1/FOXO1A Antibody (YA430) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1/FOXO1A.

HY-P810550

	*Phospho-FOXO1A* (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26) Antibody (YA9819)** FOXO1; FKHR; FOXO1a; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma	WB, ICC/IF, FC	Human, Mouse
	Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26) Antibody (YA9819) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-FOXO1A (Thr24)+ FOXO3A (Thr32)+ FOXO4 (Thr28)+ FOXO6 (Thr26).

HY-P85525

	FOXO1(C-term) Antibody (YA5217) FKH 1; FKH1; FKH1; FKHR; FKHR; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead box O1; Forkhead box protein O1; Forkhead box protein O1a; Forkhead in rhabdomyosarcoma; Forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1; FOXO1; FOXO1_HUMAN; FOXO1a; OTTHUMP00000018301.	WB	Human
	FOXO1(C-term) Antibody (YA5217) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FOXO1(C-term).

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FOXO1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Foxo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Foxo1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Foxo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Foxo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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