17 Results for "

Fibronectin Antibody

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "Fibronectin Antibody" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-108831A
CAS No.: 189261-10-7
Purity:  98.72%
Synonyms: AN100226; BG00002
Natalizumab (Anti-CD49d) (AN100226; BG00002) Solution is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d), blocking the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab solution inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 + T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thereby exerting anti-inflammatory and immunomodulatory activity. Natalizumab (Anti-CD49d) solution is used in the study of relapsing-remitting multiple sclerosis (RRMS) and is also applied in the research of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab (Anti-CD49d) can also prevent lymphocytes from entering the central nervous system, thus preventing acute demyelinating relapses .
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3
3 Cited Publications
Cat. No.: HY-108831
CAS No.: 189261-10-7
Purity:  99.10%
Natalizumab (AN100226; BG00002) is a humanized monoclonal IgG4 antibody inhibitor that selectively targets α4 integrin (CD49d). It blocks the interaction of integrins such as α4β1 (VLA-4) with vascular cell adhesion molecule VCAM-1, intercellular adhesion molecule ICAM-1, and fibronectin by competitively binding to the α4 subunit. Natalizumab inhibits the adhesion, retention, and transendothelial migration of immune cells (such as CD4 + T cells), reducing the infiltration of inflammatory cells into the central nervous system or lesion sites, thus exerting anti-inflammatory and immunomodulatory activity. Natalizumab is used in the study of relapsing-remitting multiple sclerosis (RRMS) and also has applications in the study of autoimmune or inflammation-related diseases such as Crohn's disease, B-cell lymphoma, and non-infectious uveitis. Natalizumab can also prevent lymphocytes from entering the central nervous system, thereby preventing acute demyelinating relapses .
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3
3 Cited Publications
Cat. No.: HY-P80416
Synonyms: CD49e, FNRA, ITGA5, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5

Host:  

Rabbit

Application:  

WB, ICC/IF, IHC-P, IP, FC

Reactivity:  

Human, Mouse

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2
2 Cited Publications
Cat. No.: HY-P99333
CAS No.: 558480-40-3
Synonyms: M200; Eos 200-4

Target:  

Integrin

Research Areas:  

Cardiovascular Disease Cancer

Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC50=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .
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1
1 Cited Publications
Cat. No.: HY-P80493
Synonyms: Fibronectin, FN, Fn1

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IF-Tissue

Reactivity:  

Human, Mouse

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1
1 Cited Publications
Cat. No.: HY-P80674
Synonyms: FN1; FN; Fibronectin; FN; Cold-insoluble globulin; CIG

Host:  

Mouse

Application:  

WB, IHC-F, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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1
1 Cited Publications
Cat. No.: HY-P86388
Synonyms: ITGB1; FNRB; MDF2; MSK12; Integrin beta-1; Fibronectin receptor subunit beta; VLA-4 subunit beta; CD antigen CD29

Host:  

Rabbit

Application:  

WB, IHC-P, ELISA, IF-Tissue

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P99479
CAS No.: 1957239-90-5
Synonyms: L19-IL2

Target:  

Interleukin Related

Research Areas:  

Cancer

Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity .
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Cat. No.: HY-P99296
CAS No.: 725735-28-4
Synonyms: CNTO 95; Anti-Human CD51 Recombinant Antibody

Target:  

Integrin Apoptosis

Research Areas:  

Cancer

Intetumumab (CNTO 95) is a human monoclonal antibody targeting αv integrin, with a Kd value of 1-24 nM. Through high-affinity binding to αv integrin, Intetumumab inhibits its interaction with extracellular matrix proteins (such as vitronectin and fibronectin), thereby blocking the downstream focal adhesion kinase signaling pathway. This further inhibits the adhesion, migration and invasion of tumor cells as well as the proliferation of vascular endothelial cells, promotes cell apoptosis, and exerts anti-tumor and anti-angiogenic effects. Intetumumab can be used in research related to head and neck cancer, non-small cell lung cancer and uterine serous papillary carcinoma .
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Cat. No.: HY-P990654
CAS No.: 1253180-81-2

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Radretumab is a protein that blocks myostatin that targets Fibronectin. Radretumab is a full-length Human IgG1 antibody.
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Cat. No.: HY-P991307

Research Areas:  

Cancer

BND-35 is a human monoclonal antibody (mAb) targeting LILRB4/ILT3/CD85k. BND-35 blocks the interaction of ILT3 with APOE and fibronectin, enhances the pro-inflammatory activity of various myeloid cells, and reverses ILT3-mediated immunosuppression of T cells by various suppressive myeloid cells. BND-35 has anti-tumor activity in the hILT3 transgenic mouse tumor model .
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Cat. No.: HY-P992228

Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Anti-Fibronectin III Antibody is a monoclonal antibody targeting Fibronectin III. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Fibronectin III Antibody, please refer to Mouse IgG2a kappa, Isotype Control (HY-P99978).
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Cat. No.: HY-P86415
Synonyms: FN1; FN; Fibronectin; FN; Cold-insoluble globulin; CIG

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P87519
Synonyms: FRCP2, FNDC5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P992066

Research Areas:  

Inflammation/Immunology

Anti-Mouse DDR2 Antibody (DAB0065) is a mAb that specifically targets mouse discoidin domain receptor DDR2 without cross-reacting with DDR1. Anti-Mouse DDR2 Antibody (DAB0065) binds to the extracellular domain of native mouse DDR2, induces endocytosis and lysosomal degradation of DDR2, and this process is independent of collagen binding. Anti-Mouse DDR2 Antibody (DAB0065) exhibits significant therapeutic effects in both the unilateral ureteral obstruction (UUO) mouse model of renal fibrosis and the bleomycin (HY-108345)-induced mouse model of pulmonary fibrosis, effectively downregulating the mRNA expression of type I collagen Col1a1 and fibronectin Fn1. Anti-Mouse DDR2 Antibody (DAB0065) can be humanized and has the potential to be developed as a targeted agent for diseases such as idiopathic pulmonary fibrosis and renal fibrosis .
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Cat. No.: HY-P85230
Synonyms: ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, IF-Tissue, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P85439
Synonyms: ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e

Host:  

Mouse

Application:  

WB, FC

Reactivity:  

Human, Mouse, Rat, Bovine

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