1. Inhibitory Antibodies
  2. Bifikafusp alfa

Bifikafusp alfa  (Synonyms: L19-IL2)

Cat. No.: HY-P99479

Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity.

For research use only. We do not sell to patients.

Bifikafusp alfa Chemical Structure

Bifikafusp alfa Chemical Structure

CAS No. : 1957239-90-5

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Description

Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity[1].

In Vivo

Bifikafusp alfa (1.43 and 4.29 MIU/kg; i.p.; daily; for 10 days; Female NMRI nude mice with MiaPaca-A2 xenografts) has antitumor activity against established pancreatic cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NMRI nude mice with MiaPaca-A2 xenografts[1]
Dosage: 1.43 and 4.29 MIU/kg
Administration: Intraperitoneal injection; daily; for 10 days
Result: Reduced tumor volume to 21.4% (1.43 MIU/kg) and 2.7% (4.29 MIU/kg) compared with control mice.
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[Bifikafusp alfa]

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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