FNDC5 Antibody (YA7203)
(Synonyms: FRCP2, FNDC5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2)Based on 1 Customer Validation
FNDC5 Antibody (YA7203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FNDC5.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
FNDC5 Antibody (YA7203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FNDC5.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Human
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 24 kDa
A synthesized peptide derived from human FNDC5
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FNDC5 mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA
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Subcellular Localization
Cell membrane,Peroxisome membrane,Secreted
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Expression
Tissue_Specificity: Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen
Induction: Up-regulated twofold by muscular exercise at the mRNA and protein level; this effect has been suggested to be mediated by PPARGC1A (PubMed:22237023). However, up-regulation at the mRNA level upon exercise could not be reproduced in another study (PubMed:24040023)|Present in sedentary individuals with significantly increased levels in individuals undergoing aerobic interval training -
Isoforms & Post-Translational Modification
Q8NAU1 has four isomers: Q8NAU1-5: 28283 Da (predicted); Q8NAU1-2: 24906 Da (predicted); Q8NAU1-3: 17323 Da (predicted); Q8NAU1-4: 15527 Da (predicted).
The extracellular domain is cleaved and released from the cell membrane丨N-Glycosylated -
Subunit
Dimer; may exist in other oligomeric forms
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SwissProt ID
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Synonyms
FRCP2, FNDC5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2
Documentation
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