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Results for "

GRN

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

3

Recombinant Proteins

1

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P4073
    ANG1005

    GRN1005; Paclitaxel trevatide

    		 Peptide-Drug Conjugates (PDCs) LDLR Cancer
    ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .
    ANG1005
  • HY-12854
    Imetelstat

    GRN163L

    		 Telomerase Apoptosis Cardiovascular Disease Cancer
    Imetelstat (GRN163L) is a 13-mer oligonucleotide and competitive Telomerase inhibitor. Imetelstat binds with high affinity to the template region of the RNA component of human telomerase. Imetelstat induces Apoptosis. Imetelstat is capable of selectively eliminating myelofibrosis hematopoietic stem cells. Imetelstat leads to the loss of a cancer cell's ability to maintain telomere length, resulting in the inhibition of cell proliferation .
    Imetelstat
  • HY-P99688
    Latozinemab
    1 Publications Verification

    AL001

    		 Neurotensin Receptor Neurological Disease Cancer
    Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research .
    Latozinemab
  • HY-115733
    Cathepsin L-IN-2
    1 Publications Verification

    (Rac)-Z-Phe-Phe-FMK

    		 Cathepsin Cancer
    Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
    Cathepsin L-IN-2
  • HY-124393
    GRN-529

    		mGluR Neurological Disease
    GRN-529 is a negative allosteric modulator (NAM) for mGluR5. GRN-259 modulates sleep-wake activity, and exhibits anxiolytic efficacy in rats .
    GRN-529
  • HY-RS17678
    Grn Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Grn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Grn Mouse Pre-designed siRNA Set A
    Grn Mouse Pre-designed siRNA Set A
  • HY-RS05843
    GRN Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GRN Human Pre-designed siRNA Set A contains three designed siRNAs for GRN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GRN Human Pre-designed siRNA Set A
    GRN Human Pre-designed siRNA Set A
  • HY-RS24139
    Grn Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Grn Rat Pre-designed siRNA Set A contains three designed siRNAs for Grn gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Grn Rat Pre-designed siRNA Set A
    Grn Rat Pre-designed siRNA Set A

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