1075214-55-9

ANG1005 Chemical Structure
1075214-55-9

Chemical Structure

ANG1005

Synonym(s): GRN1005; Paclitaxel trevatide

  • CAS. Nr.: 1075214-55-9
  • Formula:C257H308N32O79
  • Molecular Weight:5109.36

IUPAC Name: (4aR,4bS,6aS,8S,9aS,9bS,9cS,10aS,10bR,Z)-7-(1-((R)-4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethylidene)-10b-hydroxy-4a,6a-dimethyl-4-oxo-4,4a,4b,5,6,6a,7,8,9,9a,9b,9c,10a,10b-tetradecahydro-1H-cyclopenta[1,2]phenanthro[9,10-b]oxiren-8-yl acetate

SMILES: O=C([C@@H](NC(CCC(O[C@H]([C@H](C1=CC=CC=C1)NC(C2=CC=CC=C2)=O)C(O[C@@H]3C(C)=C([C@H](C([C@]4(C)[C@H](C[C@@]([H])(OC5)[C@]5(OC(C)=O)[C@]4([C@@H]([C@@]6(C3)O)OC(C7=CC=CC=C7)=O)[H])O)=O)OC(C)=O)C6(C)C)=O)=O)=O)[C@@H](C)O)N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC8=CC=C(O)C=C8)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CCCCNC(CCC(O[C@H]([C@H](C9=CC=CC=C9)NC(C%10=CC=CC=C%10)=O)C(O[C@@H]%11C(C)=C([C@H](C([C@]%12(C)[C@H](C[C@@]([H])(OC%13)[C@]%13(OC(C)=O)[C@]%12([C@@H]([C@@]%14(C%11)O)OC(C%15=CC=CC=C%15)=O)[H])O)=O)OC(C)=O)C%14(C)C)=O)=O)=O)=O)CC%16=CC=CC=C%16)=O)CC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCCNC(CCC(O[C@H]([C@H](C%17=CC=CC=C%17)NC(C%18=CC=CC=C%18)=O)C(O[C@@H]%19C(C)=C([C@H](C([C@]%20(C)[C@H](C[C@@]([H])(OC%21)[C@]%21(OC(C)=O)[C@]%20([C@@H]([C@@]%22(C%19)O)OC(C%23=CC=CC=C%23)=O)[H])O)=O)OC(C)=O)C%22(C)C)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CO)=O)=O)=O)CC%24=CC=C(O)C=C%24)=O)CC%25=CC=CC=C%25)=O)CC%26=CC=CC=C%26

Biological Activity: ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system[1][2][3].

Art. -Nr. Produktname Reinheit Beschreibung Pricing
HY-P4073
ANG1005 98.83% ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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References