108005-94-3
Chemical Structure
Cathepsin L-IN-2
Synonym(s): (Rac)-Z-Phe-Phe-FMK
- CAS No.: 108005-94-3
- Formula:C27H27FN2O4
- Molecular Weight:462.51
IUPAC Name: benzyl (1-((4-fluoro-3-oxo-1-phenylbutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
InChIKey: CAILNONEKASNSH-UHFFFAOYSA-N
SMILES: O=C(OCC1=CC=CC=C1)NC(CC2=CC=CC=C2)C(NC(CC3=CC=CC=C3)C(CF)=O)=O
Biological Activity: Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cathepsin L-IN-2 | 98.02% | Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis. | ||||||||||||||||||||
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Keywords
