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Results for "

GluR1

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Recombinant Proteins

6

Antibodies

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101528
    IDRA 21

    		iGluR Neurological Disease
    IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging [1].
    IDRA 21
  • HY-12509
    PEPA

    		iGluR Neurological Disease
    PEPA is an AMPA receptor allosteric potentiator. PEPA shows preferential action of PEPA on the flop form of AMPA receptors. PEPA is a more potent suppressor of desensitization of receptors containing GluR3 and GluR4 as opposed to those containing GluR1. PEPA has antianxiety effects [1] .
    PEPA
  • HY-104020A
    Philanthotoxin 74 dihydrochloride

    PhTx 74 dihydrochloride

    		 iGluR Neurological Disease
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively [1] .
    Philanthotoxin 74 dihydrochloride
  • HY-13456
    LY-404187

    		iGluR Neurological Disease
    LY-404187 is a potent, selective and centrally active positive allosteric modulator of AMPA receptors, with the EC50s of 5.65, 0.15, 1.44, 1.66 and 0.21 µM for GluR1i, GluR2i, GluR2o, GluR3i and GluR4i, respectively. LY-404187 has therapeutic potential in a number of psychiatric disorders and neurodegenerative diseases [1] .
    LY-404187
  • HY-19433A
    (S)-ATPO

    		iGluR Neurological Disease
    (S)-ATPO is the (S)-enantiomer of ATPO, which is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors [1].
    (S)-ATPO
  • HY-103229
    Cl-HIBO

    		iGluR Neurological Disease
    Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties [1].
    Cl-HIBO
  • HY-104020B
    Philanthotoxin 74 diTFA

    PhTx 74 diTFA

    		 iGluR Neurological Disease
    Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively [1] .
    Philanthotoxin 74 diTFA
  • HY-101528R
    IDRA 21 (Standard)

    		iGluR Reference Standards Neurological Disease
    IDRA 21 (Standard) is the analytical standard of IDRA 21 (HY-101528). This product is intended for research and analytical applications. IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging [1].
    IDRA 21 (Standard)
  • HY-RS05791
    GRIA1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GRIA1 Human Pre-designed siRNA Set A contains three designed siRNAs for GRIA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GRIA1 Human Pre-designed siRNA Set A
    GRIA1 Human Pre-designed siRNA Set A
  • HY-131691
    NMDAR blocker 1

    		iGluR Calcium Channel Neurological Disease
    NMDAR blocker 1 is an NMDA receptor channel blocker with an IC50 of 5.0 μM. NMDAR blocker 1 exhibits fast on-off blockade kinetics and strong voltage dependence, and does not compete with glutamate or glycine. NMDAR blocker 1 prevents glutamate/NMDA-induced intracellular Ca 2+ overload, modulates the glutamate-nitric oxide-cGMP pathway. NMDAR blocker 1 prevents in vitro excitotoxic neurodegeneration of cultured cerebellar and hippocampal neurons. NMDAR blocker 1 attenuates excitotoxic insult in an mouse model of hyperammonemia-induced excitotoxicity. NMDAR blocker 1 can be used for the research of neurodegenerative diseases [1].
    NMDAR blocker 1

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