401601-12-5
401601-12-5
Chemical Structure
Philanthotoxin 74 diTFA
Synonym(s): PhTx 74 diTFA
- No. CAS: 401601-12-5
- Formula:C28H44F6N4O7
- Molecular Weight:662.66
IUPAC Name: (S)-N-(1-((7-((4-aminobutyl)amino)heptyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)butyramide bis(2,2,2-trifluoroacetate)
InChIKey: JRVVNHLVJQBVGK-IKXQUJFKSA-N
SMILES: O=C(NCCCCCCCNCCCCN)[C@@H](NC(CCC)=O)CC1=CC=C(O)C=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Biological Activity: Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively[1][2].
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Philanthotoxin 74 diTFA | Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. | |||||||||||||||||||||
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References
- [1]. Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8. [Content Brief]
- [2]. Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45(26):5745-54. [Content Brief]
Keywords
