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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
55 Results for "
Hex
" in MedChemExpress (MCE) Product Catalog:
Products (55)
55 Results for "Hex" in MCE Product Catalog:
4
4 Cited Publications
Forschungsgebiete:
POMHEX, a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) proagent of HEX, is a potent, ENO2-specific inhibitor of enolase. POMHEX exhibits low-nanomolar potency against ENO1-deleted cells in vitro and is capable of eradicating ENO1-deleted xenografted tumours in vivo. POMHEX is a potent glycolysis inhibitor .
4
4 Cited Publications
Synonyms: Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide
Target:
Forschungsgebiete:
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
2
2 Cited Publications
Target:
Forschungsgebiete:
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC50s of 6.0 μM and 3.1 μM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM .
1
1 Cited Publications
1
1 Cited Publications
Art. -Nr.: HY-P0302
CAS. Nr.: 688805-40-5
Target:
Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC50s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors .
Art. -Nr.: HY-W010532
CAS. Nr.: 1577-18-0
Synonyms: (E)-Hex-3-enoic acid
Art. -Nr.: HY-Y0925
CAS. Nr.: 53293-00-8
Synonyms: Hex-5-ynoic acid
Target:
Forschungsgebiete:
5-Hexynoic acid (Hex-5-ynoic acid) is an alkynoic acid. 5-Hexynoic acid serves as a drug intermediate for the synthesis of 3-alkoxy-2-cyclohexenone .
Art. -Nr.: HY-W015936
CAS. Nr.: 928-95-0
Synonyms: trans-Hex-2-en-1-ol
Category:
Art. -Nr.: HY-N2426
CAS. Nr.: 119738-57-7
Target:
Art. -Nr.: HY-W015943
CAS. Nr.: 928-90-5
Synonyms: 5-Hexyn-1-ol
Target:
Forschungsgebiete:
Hex-5-yn-1-ol (5-Hexyn-1-ol) is a PROTAC linker that can be used in the synthesis of PROTACs.
Art. -Nr.: HY-34643
CAS. Nr.: 30964-00-2
Synonyms: Hept-6-ynoic acid
Target:
Forschungsgebiete:
Hexanoylic acid (Hex-6-ynoic acid) is a drug intermediate. Hexanoylic acid can be functionalized by esterification reaction to paclitaxel (HY-B0015), enabling it to undergo an efficient ring addition reaction with β-cyclodextrin, thereby enhancing its water solubility, stability and targeting properties .
Synonyms: ASN90
Target:
Forschungsgebiete:
Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
Art. -Nr.: HY-W050829
CAS. Nr.: 151978-58-4
Target:
Forschungsgebiete:
tert-Butyl hex-5-yn-1-ylcarbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
Art. -Nr.: HY-W010531
CAS. Nr.: 13419-69-7
Synonyms: trans-2-Hexenoic acid
Art. -Nr.: HY-161242A
Target:
Forschungsgebiete:
CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex .
Art. -Nr.: HY-D0828
CAS. Nr.: 137071-78-4
Art. -Nr.: HY-D0829
CAS. Nr.: 81742-10-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
