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M-31850 

Cat. No.: HY-104050
Handling Instructions

M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC50s of 6.0 µM and 3.1 µM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.

For research use only. We do not sell to patients.

M-31850 Chemical Structure

M-31850 Chemical Structure

CAS No. : 281224-40-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 90 In-stock
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50 mg USD 120 In-stock
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100 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC50s of 6.0 µM and 3.1 µM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM[1][2].

IC50 & Target

IC50: 6.0 µM (human HexA) and 3.1 µM (human HexB)[1].
Ki: 2.5 μM (OfHex2)[2]

In Vitro

M-31850 shows some activity towards Jack Bean Hex (JBHex) and bacterial Hex from Streptomyces plicatus (SpHex) (IC50 of 280 µM and >500 µM for JBHex and SpHex, respectively)[1].
M-31850 produces a dose dependent increase in MUG hydrolysis (Hex S levels) in lysates from treated infantile Sandhoff disease (ISD) cells[1].
M-31850 increases the half-life of the mutant Hex A from Adult forms of Tay-Sachs (ATSD) cells more than two-fold at 44° C, relative to the enzyme heated in the presence of DMSO. M-31850 acts as a classic competitive inhibitor of Hex (Km increases and Vmax is unaffected by increasing amounts of M-31850), with a Ki of 0.8 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

463.48

Formula

C₂₈H₂₁N₃O₄

CAS No.

281224-40-6

SMILES

O=C(C1=CC=CC2=C1C3=CC=C2)N(CCNCCN4C(C5=CC=CC6=C5C(C4=O)=CC=C6)=O)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.79 mM; ultrasonic and adjust pH to 6 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1576 mL 10.7880 mL 21.5759 mL
5 mM 0.4315 mL 2.1576 mL 4.3152 mL
10 mM 0.2158 mL 1.0788 mL 2.1576 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

M-31850M31850M 31850Othersβ-N-acetyl-D-hexosaminidasesnon-carbohydrateOfHex2β-hexosaminidaseInhibitorinhibitorinhibit

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M-31850
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HY-104050
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